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GEMAZA™ lyophilisate for injection solution 5000IU, 5pcs

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Table of Contents

GEMAZA™ 5000IU Lyophilisate 5pcs Buy Online

GEMAZA: A Fibrinolytic Agent

GEMAZA is a powerful fibrinolytic agent, playing a crucial role in the breakdown of blood clots. Its mechanism of action centers on the targeted conversion of plasminogen to plasmin, a vital enzyme responsible for dissolving fibrin clots.

This recombinant human pro-urokinase, a serine protease, offers a targeted approach to clot dissolution. The 5000 IU dosage is precisely formulated for effective therapeutic intervention, offering a controlled and targeted approach to clot management. Its single-chain molecule structure facilitates efficient delivery and action.

Understanding its unique properties is key to appreciating its therapeutic potential. The precise molecular weight and structure of GEMAZA contribute to its efficacy in various clinical situations. This makes it a valuable tool in specific medical contexts requiring controlled fibrinolysis.

Understanding GEMAZA’s Mechanism of Action

GEMAZA’s therapeutic effect stems from its ability to efficiently dissolve blood clots. This fibrinolytic action is achieved through a precise mechanism involving the activation of plasminogen. Specifically, GEMAZA, a recombinant human pro-urokinase, acts as a catalyst, converting inactive plasminogen into its active form, plasmin.

Plasmin, a powerful enzyme, then targets and breaks down fibrin, the protein that forms the structural basis of blood clots. This targeted degradation of fibrin leads to the dissolution of the clot, restoring normal blood flow. The process is carefully controlled, ensuring targeted clot breakdown without excessive systemic effects.

The efficiency of this process is directly linked to GEMAZA’s unique molecular structure. Its single-chain molecule design with a molecular mass of approximately 54,000 Daltons facilitates optimal interaction with plasminogen. This precise interaction is key to its effectiveness as a selective fibrinolytic agent. The controlled conversion of plasminogen to plasmin minimizes the risk of unwanted bleeding complications.

Unlike some other thrombolytic agents, GEMAZA’s action is primarily focused on the fibrin within the clot. This selectivity is a significant advantage, reducing the risk of excessive systemic fibrinolysis and associated bleeding complications. The precise molecular weight and structure contribute to the drug’s targeted action within the clot itself.

This targeted approach distinguishes GEMAZA from other thrombolytic agents, enhancing its safety profile. The precise control of plasmin generation minimizes the risk of widespread clot breakdown, reducing the likelihood of significant bleeding. The drug’s action is confined largely to the area of the clot itself, further reducing systemic side effects.

Key Features of GEMAZA 5000 IU

The 5000 IU formulation of GEMAZA offers several key advantages contributing to its efficacy and safety profile. Its precise dosage ensures controlled and targeted fibrinolysis, minimizing the risk of excessive bleeding. This precise dose is crucial for managing clot dissolution effectively.

Presented as a lyophilized powder, GEMAZA requires reconstitution before administration. This form ensures the stability and potency of the active ingredient, maintaining its effectiveness until needed. The lyophilized form facilitates convenient storage and transport.

Each vial contains a precise amount of recombinant human pro-urokinase, ensuring consistent dosing and predictable therapeutic outcomes. The use of recombinant technology ensures high purity and consistency in each dose. This consistency is crucial for reliable therapeutic effects.

The inclusion of excipients such as sodium chloride and dextran 40 in the formulation aids in the reconstitution process and contributes to the stability of the reconstituted solution. These excipients help maintain the integrity and stability of the active ingredient. Their inclusion is essential for optimal drug delivery.

The single-chain molecule structure of the active ingredient, recombinant human pro-urokinase, is designed for optimal interaction with plasminogen, enhancing the efficiency of clot breakdown. This structure is crucial for its potent fibrinolytic action. The precise molecular weight further contributes to its targeted action.

The 5000 IU dose is specifically designed for targeted therapeutic applications, balancing efficacy with safety. Careful consideration of the dosage is crucial for achieving therapeutic benefits while minimizing the risk of adverse effects. The balance of efficacy and safety is a key feature of this product.

Therapeutic Applications of GEMAZA

GEMAZA’s primary therapeutic application lies in its ability to effectively dissolve blood clots, making it a valuable tool in various medical situations. Its targeted action on fibrin, the protein forming the clot structure, makes it particularly suitable for conditions where localized clot breakdown is desired. This targeted action minimizes systemic side effects.

In ophthalmology, GEMAZA finds significant use in managing various conditions involving intraocular bleeding and clot formation. Specific applications include the treatment of hyphema, vitreous hemorrhage, and retinal vascular occlusions. The drug’s ability to safely dissolve clots within the eye is crucial for preserving vision.

The precise mechanism of action, focusing on fibrinolysis within the clot itself, minimizes the risk of systemic bleeding complications. This targeted approach is particularly important in ophthalmologic applications, where excessive bleeding could be detrimental. The controlled nature of its action makes it a safer option.

While primarily known for its ophthalmological applications, GEMAZA’s fibrinolytic properties may also be relevant in other clinical settings requiring controlled clot dissolution. Although less common, further research may reveal additional therapeutic applications. The potential for wider use remains a subject of ongoing study.

The drug’s ability to dissolve clots without causing widespread systemic effects distinguishes it. This targeted approach is crucial in delicate areas such as the eye, where uncontrolled bleeding would be highly problematic. Its controlled action contributes to its overall safety profile.

The versatility of GEMAZA stems from its ability to target and dissolve clots without causing widespread systemic effects. This targeted approach makes it a valuable tool in situations requiring precise clot dissolution in specific areas, minimizing the risk of uncontrolled bleeding or other complications. This targeted approach is paramount for its effectiveness and safety.

Advantages of GEMAZA

GEMAZA offers several key advantages as a fibrinolytic agent, making it a valuable therapeutic option in specific clinical scenarios. Its targeted mechanism of action, focusing primarily on the fibrin within the blood clot, minimizes the risk of excessive systemic fibrinolysis and related bleeding complications. This selective action is a significant advantage over some broader-acting thrombolytics.

The precise 5000 IU dosage allows for controlled and predictable clot dissolution. This controlled approach is particularly beneficial in sensitive areas such as the eye, where excessive bleeding could have severe consequences. The precise dosing contributes to both efficacy and safety.

GEMAZA’s formulation as a lyophilized powder ensures its stability and potency, maintaining its effectiveness until reconstitution. This stable form is ideal for storage and transport, ensuring the drug’s quality remains intact. The ease of storage and transport contributes to its practicality.

The use of recombinant human pro-urokinase ensures a high level of purity and consistency, leading to reliable therapeutic outcomes. This consistent quality is crucial for predicting therapeutic effects and minimizing variability in patient response. Reliable and consistent results are an important advantage.

The drug’s relatively rapid action, compared to some other fibrinolytic agents, allows for prompt treatment and faster resolution of clot-related issues. The speed of its action is beneficial in time-sensitive situations. This rapid action can be crucial in certain medical emergencies.

Finally, GEMAZA’s established safety profile in its approved applications further enhances its value as a therapeutic option. The extensive clinical experience with the drug provides confidence in its safety and effectiveness. A strong safety profile is always a key advantage in medical treatments.

Disadvantages of GEMAZA

While GEMAZA offers significant advantages as a fibrinolytic agent, it’s crucial to acknowledge potential drawbacks. The most significant risk associated with GEMAZA, as with all thrombolytic therapies, is the potential for bleeding complications. Although targeted, the drug’s action on fibrin can, in some cases, lead to bleeding at the injection site or even more serious systemic bleeding.

The need for careful patient selection and monitoring is paramount to minimize this risk. Pre-existing conditions that increase bleeding risk, such as recent trauma or active bleeding disorders, necessitate careful consideration before administering GEMAZA. Thorough assessment of the patient’s overall health is essential.

Another potential drawback is the requirement for reconstitution before administration. This additional step adds complexity to the administration process, requiring trained medical personnel to prepare the solution correctly. Incorrect reconstitution could affect the drug’s efficacy or safety.

Allergic reactions, although rare, are a possibility with any pharmaceutical agent. While infrequent, the potential for hypersensitivity reactions must be considered. Patients with a history of allergies should be carefully monitored after administration.

Furthermore, the availability of GEMAZA may be limited in certain regions, potentially impacting access for patients who could benefit from its fibrinolytic properties. Geographical limitations in availability can be a practical constraint for some patients. Access to the drug may vary depending on location.

Finally, the cost of GEMAZA, relative to other treatment options, may be a factor in its overall suitability for some patients or healthcare systems. Cost considerations can influence the choice of treatment in certain situations. Economic factors may play a role in treatment decisions.

Dosage and Administration

The standard dosage of GEMAZA is 5000 IU, delivered via injection. However, the specific route and frequency of administration depend heavily on the clinical indication and the patient’s individual condition. Dosage adjustments are always determined by the treating physician based on a complete assessment of the patient’s needs.

For ophthalmological applications, GEMAZA is typically administered via intravitreal, subconjunctival, or parabulbar injection. The precise injection technique is selected based on the location and nature of the clot. The route of administration is crucial for effective and safe drug delivery.

Before administration, the lyophilized GEMAZA must be carefully reconstituted using a sterile diluent, usually 0.9% sodium chloride solution. The reconstitution process requires strict adherence to aseptic techniques to prevent contamination. Proper reconstitution ensures the drug’s potency and safety.

The number of injections needed varies considerably depending on the severity of the condition and the patient’s response. A course of treatment might involve multiple injections, spaced appropriately according to the physician’s instructions. The treatment plan is individualized for each patient.

Close monitoring of the patient is essential throughout the treatment course. Regular assessment of the patient’s condition, including monitoring for signs of bleeding, is crucial. Careful observation is crucial for early detection of any complications.

It’s imperative that GEMAZA is administered only by trained medical professionals experienced in handling thrombolytic agents. The administration should be performed under appropriate medical supervision. This ensures safe and effective administration of the drug.

Contraindications and Precautions

GEMAZA, like all medications, has specific contraindications and requires careful consideration of potential risks before administration. A critical contraindication is the presence of active bleeding, or a significantly increased risk of bleeding. Conditions such as recent trauma, active peptic ulcers, or bleeding disorders necessitate avoiding GEMAZA use.

Patients with a history of hypersensitivity reactions to GEMAZA or any of its components should avoid its use. A thorough allergy history should be obtained before administration to minimize the risk of allergic reactions. Careful monitoring for allergic responses is essential.

Caution is advised in patients with conditions that might increase the risk of bleeding, such as severe hypertension or liver disease. These conditions require careful assessment before using GEMAZA to minimize risks. A comprehensive evaluation of the patient’s condition is crucial.

Patients receiving concurrent anticoagulant or antiplatelet therapy require careful monitoring when considering GEMAZA. Such therapies can significantly enhance the risk of bleeding when combined with GEMAZA. The potential for drug interactions necessitates careful consideration.

Pregnancy and breastfeeding should be carefully considered before administering GEMAZA, as the safety profile in these conditions is not fully established. Further research is needed to fully understand the drug’s effects on pregnant women and nursing mothers. A careful risk-benefit assessment is necessary.

Finally, elderly patients, who are often more susceptible to bleeding complications, require particularly close monitoring during and after GEMAZA administration. This increased vigilance is important to mitigate the risk of adverse events in this vulnerable population. Careful consideration of age-related factors is paramount.

Conclusion

GEMAZA, a fibrinolytic agent, presents a valuable tool in managing specific conditions characterized by localized clot formation, particularly in ophthalmology. Its targeted mechanism of action, focusing on fibrin degradation within the clot, offers a significant advantage by minimizing the risk of systemic bleeding complications often associated with broader-acting thrombolytics. The precise 5000 IU dosage further contributes to its controlled and predictable therapeutic effect.

However, the potential for bleeding, although minimized by its targeted action, remains a critical consideration. Careful patient selection, meticulous administration techniques, and close monitoring are essential to ensure safe and effective treatment. The benefits of GEMAZA must always be weighed against the potential risks on a case-by-case basis.

While GEMAZA demonstrates clear advantages in specific clinical settings, particularly in ophthalmology, its use should be restricted to cases where the benefits outweigh the inherent risks of bleeding. The drug’s efficacy and safety profile underscore the importance of proper patient selection and adherence to strict administration protocols. Only trained medical professionals should administer GEMAZA.

Further research may expand our understanding of GEMAZA’s potential applications beyond its currently approved uses. Ongoing studies could reveal additional therapeutic benefits and refine our understanding of its safety profile. Continuous evaluation and research are essential for optimizing the use of this important therapeutic agent.

In summary, GEMAZA offers a valuable therapeutic option for conditions involving localized clot formation, but its use necessitates a thorough understanding of its mechanism of action, potential risks, and appropriate administration techniques. Responsible and informed use is paramount to maximizing its benefits while minimizing potential harm.

The targeted fibrinolytic action of GEMAZA positions it as a valuable addition to the therapeutic arsenal for selected conditions, but careful patient selection and precise administration remain critical for ensuring its safe and effective use. Appropriate medical supervision is always essential when using GEMAZA.

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