DALNEVA™ tablets 10mg+4mg, 30pcs

DALNEVA™ 10mg+4mg Tablets Buy Online

Understanding DALNEVA Tablets

DALNEVA tablets offer a combined approach to managing high blood pressure and angina. This dual-action formulation provides a comprehensive solution for patients requiring both ACE inhibitor and calcium channel blocker therapy.

The medication combines perindopril erbumine, an ACE inhibitor, and amlodipine, a calcium channel blocker. This unique combination works synergistically to effectively control blood pressure and improve cardiovascular health.

Understanding the individual roles of each component is crucial for comprehending DALNEVA’s overall efficacy. Perindopril relaxes blood vessels, while amlodipine further reduces vascular resistance and improves blood flow to the heart.

DALNEVA is typically administered once daily, usually in the morning. The tablets should be swallowed whole with water and not chewed. Always adhere to your doctor’s prescribed dosage and regimen for optimal results.

What is DALNEVA?

DALNEVA is a combination medication used in the treatment of high blood pressure (hypertension) and/or stable angina. It’s a carefully formulated blend of two active ingredients that work together to address these cardiovascular conditions. This synergistic action offers a potentially more effective approach than using either component alone.

The key benefit of DALNEVA lies in its dual mechanism of action. It combines the effects of an ACE inhibitor (perindopril erbumine) and a calcium channel blocker (amlodipine). These components target different aspects of cardiovascular function, resulting in a comprehensive approach to blood pressure and heart health management.

Specifically, perindopril helps relax blood vessels, reducing resistance to blood flow. Amlodipine further facilitates this process by relaxing the muscles in the blood vessel walls, further improving blood flow. This dual action leads to a more significant reduction in blood pressure and improved blood flow to the heart muscle, relieving angina symptoms.

DALNEVA is available in tablet form, and the dosage should always be determined and monitored by a healthcare professional. The precise dosage will depend on individual needs and response to treatment. It is crucial to follow your doctor’s instructions carefully to maximize the therapeutic benefits and minimize the potential for side effects.

Mechanism of Action

DALNEVA’s effectiveness stems from the combined action of its two active components: perindopril erbumine and amlodipine. These work synergistically to lower blood pressure and alleviate angina symptoms through distinct yet complementary mechanisms.

Perindopril erbumine, an angiotensin-converting enzyme (ACE) inhibitor, primarily works by blocking the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels. By inhibiting this conversion, perindopril helps to relax and widen blood vessels, thus lowering blood pressure.

Amlodipine, a calcium channel blocker, acts by relaxing the muscles in the walls of blood vessels. This relaxation further reduces vascular resistance, leading to lower blood pressure and improved blood flow. Amlodipine also dilates coronary arteries, increasing oxygen supply to the heart, thereby alleviating angina symptoms.

The combined effect of these two mechanisms results in a more significant and sustained reduction in blood pressure compared to using either drug alone. This dual action makes DALNEVA a powerful tool in managing both hypertension and angina, offering patients a comprehensive approach to cardiovascular health improvement. The precise interplay between these two components results in a substantial and sustained reduction in blood pressure, significantly benefiting patients with both conditions.

Indications for Use

DALNEVA tablets are primarily indicated for the management of arterial hypertension, commonly known as high blood pressure. This condition, if left untreated, can significantly increase the risk of serious cardiovascular complications such as stroke, heart attack, and kidney disease. DALNEVA’s dual-action mechanism makes it effective in reducing blood pressure to healthier levels.

In addition to hypertension, DALNEVA is also prescribed for patients with stable angina pectoris. Angina is characterized by chest pain or discomfort due to reduced blood flow to the heart muscle. DALNEVA’s ability to dilate coronary arteries improves blood flow, providing relief from angina symptoms and reducing the risk of future cardiac events.

It’s crucial to note that DALNEVA is typically prescribed for patients who require both ACE inhibitor and calcium channel blocker therapy. Your doctor will assess your individual needs and medical history to determine if DALNEVA is the appropriate treatment for your specific condition. Always discuss your treatment options with a healthcare professional before starting any new medication regimen.

The use of DALNEVA should be guided by a physician’s assessment of individual patient needs and risk factors. It is not a first-line treatment for all cases of hypertension or angina, and its suitability should be carefully considered based on a comprehensive evaluation of the patient’s health status. Self-medication is strongly discouraged; always seek professional medical advice.

Dosage and Administration

DALNEVA tablets are typically administered orally, once daily. The recommended time of administration is usually in the morning, preferably before a meal. This timing helps to maintain consistent blood levels of the active ingredients throughout the day, optimizing therapeutic efficacy. Always follow your doctor’s instructions regarding dosage and timing.

Each tablet should be swallowed whole with a sufficient amount of water. Chewing or crushing the tablets should be avoided, as this can alter the drug’s release profile and potentially affect its effectiveness. Consistency in administration is crucial for achieving the desired therapeutic outcome.

The dosage of DALNEVA is individualized based on the patient’s specific needs and response to treatment. Your doctor will determine the appropriate dose, starting with a lower dose and potentially adjusting it over time to achieve optimal blood pressure control and angina symptom relief. Regular monitoring of blood pressure is essential to ensure the prescribed dose remains effective and safe.

It is imperative to consult with your healthcare provider before altering the prescribed dosage or discontinuing the medication. Sudden changes in dosage can have negative consequences, and adjustments should only be made under the guidance of a medical professional. Your doctor will work with you to personalize the dosage regimen and monitor your progress closely.

Potential Benefits (Pros)

DALNEVA offers several key advantages for patients managing hypertension and angina. Its dual mechanism of action, combining an ACE inhibitor and a calcium channel blocker, provides a comprehensive approach to cardiovascular health. This synergistic effect often leads to superior blood pressure control compared to monotherapy.

By effectively lowering blood pressure, DALNEVA helps to reduce the risk of serious cardiovascular complications. These include stroke, heart attack, and kidney disease, all of which are significantly influenced by high blood pressure. The reduction in blood pressure contributes to overall improved cardiovascular health and well-being.

For patients experiencing angina, DALNEVA offers relief from chest pain and discomfort. The medication’s ability to dilate coronary arteries improves blood flow to the heart muscle, increasing oxygen supply and reducing the frequency and severity of angina episodes. This improved blood flow contributes to enhanced cardiac function and reduced angina-related symptoms.

Many patients find that DALNEVA’s once-daily dosage regimen improves convenience and adherence to treatment. The single-tablet administration simplifies medication management, potentially improving patient compliance and leading to better long-term outcomes. This simplicity promotes consistent medication use, which is crucial for effective blood pressure and angina control.

Pros

Effective Blood Pressure Control: DALNEVA’s dual-action mechanism provides superior hypertension management. Improved Angina Relief: Enhanced blood flow to the heart reduces chest pain. Convenient Once-Daily Dosage: Simplifies medication routine and improves adherence.

Potential Risks (Cons)

While DALNEVA offers significant benefits, it’s crucial to be aware of potential side effects. Like all medications, DALNEVA can cause adverse reactions, although not everyone experiences them. The frequency and severity of side effects vary among individuals, and some may be more susceptible than others.

Some common side effects associated with ACE inhibitors like perindopril include dry cough, dizziness, headache, and fatigue. These are usually mild and transient, often resolving as the body adjusts to the medication. However, if these persist or worsen, consult your doctor immediately.

Amlodipine, the calcium channel blocker component, can also cause side effects, including edema (swelling), headache, flushing, and dizziness. More serious, though rare, side effects can include allergic reactions, liver problems, and changes in heart rhythm. Prompt medical attention is required if you experience any concerning symptoms.

It’s important to inform your doctor about your complete medical history, including any pre-existing conditions or allergies, before starting DALNEVA. This information is crucial in assessing potential risks and determining if the benefits outweigh the potential downsides for your individual circumstances. Open communication with your healthcare provider is key to safe and effective medication management.

Cons

Potential Side Effects: Dry cough, dizziness, headache, and swelling are possibilities. Serious but Rare Risks: Allergic reactions and liver problems are uncommon but require immediate medical attention. Individual Reactions Vary: Not everyone experiences side effects, and severity differs.

Pharmacokinetic Properties

Understanding the pharmacokinetic properties of DALNEVA is essential for optimizing its therapeutic use. These properties describe how the drug is absorbed, distributed, metabolized, and excreted by the body. This knowledge helps healthcare professionals determine appropriate dosages and predict potential drug interactions.

Absorption: Following oral administration, both perindopril and amlodipine are absorbed from the gastrointestinal tract. The absorption rate and extent can be influenced by factors such as food intake and individual variations in gut physiology. Peak plasma concentrations are typically reached within a few hours.

Distribution: Once absorbed, perindopril and amlodipine distribute throughout the body. Perindopril is extensively metabolized, with its active metabolite, perindoprilat, being responsible for most of its therapeutic effects. Amlodipine, on the other hand, shows relatively high plasma protein binding.

Metabolism and Excretion: Perindopril is primarily metabolized in the liver, and its metabolites are excreted through the kidneys. Amlodipine is also metabolized in the liver, but a significant portion of the drug is excreted unchanged in the urine. The pharmacokinetic profile of both components influences the duration of action and the need for once-daily dosing.

Drug Interactions: The pharmacokinetic properties of DALNEVA can be affected by other medications. Potential interactions with other drugs should be carefully considered by healthcare professionals when prescribing DALNEVA. This includes concurrent use of diuretics, other antihypertensives, or medications that are extensively metabolized by the liver. These interactions highlight the importance of comprehensive medical history review and careful monitoring during treatment.

Active Components in Detail

DALNEVA’s efficacy relies on the precise combination of two key active ingredients: perindopril erbumine and amlodipine. Understanding the individual roles of these components is crucial to appreciating the medication’s overall therapeutic effect. Their synergistic action provides a comprehensive approach to managing both hypertension and angina.

Perindopril erbumine is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the action of an enzyme that constricts blood vessels. This inhibition leads to vasodilation (widening of blood vessels), resulting in lower blood pressure and improved blood flow. The active metabolite of perindopril, perindoprilat, is responsible for most of its therapeutic effects.

Amlodipine is a calcium channel blocker of the dihydropyridine type. It works by relaxing the smooth muscles in the walls of blood vessels, causing vasodilation and reducing blood pressure. Amlodipine also dilates coronary arteries, improving blood supply to the heart muscle and alleviating angina symptoms. Its mechanism of action differs from that of perindopril, creating a complementary effect.

The combined use of perindopril and amlodipine in DALNEVA provides a more potent and comprehensive approach to treating hypertension and angina than using either drug alone. This combination allows for a wider range of therapeutic benefits, such as better blood pressure control and improved angina relief. The unique properties of each ingredient contribute to a more robust treatment strategy.

Perindopril Erbumine

Perindopril erbumine, a key component of DALNEVA, is an angiotensin-converting enzyme (ACE) inhibitor. Its mechanism of action centers on the inhibition of ACE, a crucial enzyme in the renin-angiotensin-aldosterone system (RAAS). This system plays a significant role in regulating blood pressure and fluid balance within the body.

By inhibiting ACE, perindopril erbumine prevents the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels. By blocking this conversion, perindopril erbumine promotes vasodilation, leading to a reduction in peripheral vascular resistance and consequently, lower blood pressure. This effect is a cornerstone of its antihypertensive properties.

Furthermore, the inhibition of ACE also leads to reduced aldosterone secretion. Aldosterone is a hormone that promotes sodium and water retention, contributing to increased blood volume and blood pressure. By reducing aldosterone levels, perindopril erbumine further enhances its blood pressure-lowering effect. This dual mechanism contributes significantly to the overall efficacy of DALNEVA.

In addition to its antihypertensive effects, perindopril erbumine has demonstrated beneficial effects on the cardiovascular system. Studies suggest it can help to reduce left ventricular hypertrophy (thickening of the heart muscle) and improve endothelial function. These effects contribute to the overall cardiovascular protective benefits associated with its use. These positive impacts on the heart and blood vessels make perindopril erbumine a valuable component in the treatment of both hypertension and angina.

Amlodipine

Amlodipine, the second active component in DALNEVA, is a calcium channel blocker (CCB) belonging to the dihydropyridine class. Its primary mechanism of action involves the inhibition of calcium ion influx into vascular smooth muscle cells. This inhibition leads to relaxation of the blood vessels, which is crucial for its therapeutic effects.

This vasodilation, or widening of blood vessels, is responsible for amlodipine’s antihypertensive effect. By reducing peripheral vascular resistance, amlodipine lowers blood pressure effectively and sustainably. Its action on blood vessels is a significant contributor to the overall blood pressure-lowering effects of DALNEVA.

Beyond its impact on blood pressure, amlodipine also demonstrates beneficial effects in the context of angina. Its ability to dilate coronary arteries improves blood flow to the heart muscle, increasing oxygen supply and alleviating chest pain associated with angina. This coronary dilation reduces myocardial oxygen demand, thus offering relief from angina symptoms.

Amlodipine’s unique mechanism of action complements that of perindopril in DALNEVA. While perindopril acts on the RAAS, amlodipine directly affects vascular smooth muscle. This combined action results in a more comprehensive and robust approach to treating hypertension and angina, offering patients a superior treatment strategy compared to using either drug in isolation. The combined effects on both blood vessels and the heart muscle contribute to a significant improvement in cardiovascular health.