LIKFERR100™ solution for IV injection 20mg/ml (5ml), ampoules 5pcs

LIKFERR100™ 20mg/ml Solution 5ml Buy Online

LIKFERR100 Solution for IV Injection: A Comprehensive Overview

Addressing iron deficiency effectively and swiftly is crucial for overall health. LIKFERR100, an intravenous iron solution, offers a rapid and efficient method to replenish iron levels in individuals with various conditions.

What is LIKFERR100?

LIKFERR100 is a sterile, injectable solution containing iron (III)-hydroxide sucrose complex. This complex is designed for rapid absorption and utilization by the body. It’s a colloidal solution composed of spheroidal iron-carbohydrate nanoparticles, making it suitable for intravenous administration.

The iron (III)-hydroxide sucrose complex in LIKFERR100 dissociates in the reticuloendothelial system, releasing iron for use in red blood cell production. This process helps to correct iron deficiency anemia and improve oxygen-carrying capacity of the blood. The sucrose component aids in the safe and efficient delivery of iron.

LIKFERR100 is indicated for the treatment of iron deficiency anemia, particularly in situations requiring rapid iron replenishment. It is also a suitable option for patients who cannot tolerate oral iron supplements or have gastrointestinal conditions that prevent oral administration.

Intravenous Administration

LIKFERR100 is administered intravenously, typically under the supervision of a healthcare professional. The specific dosage and administration method should always be determined by a physician based on individual patient needs and response.

Dilution for Infusion

For intravenous infusion, LIKFERR100 is typically diluted with a 0.9% sodium chloride solution. The recommended dilution ratio is usually 1:20 (1ml LIKFERR100 to 20ml of saline solution). The infusion rate should be carefully controlled to minimize potential adverse effects.

Pros of LIKFERR100

• Rapid iron replenishment: Provides a quick way to address iron deficiency.
• Suitable for patients intolerant to oral iron: An effective alternative for those who cannot take oral supplements.
• Effective in various iron deficiency conditions: Addresses a wide range of iron-related health issues.

Cons of LIKFERR100

• Potential for adverse reactions: Like all medications, LIKFERR100 may cause side effects, requiring careful monitoring.
• Requires intravenous administration: Needs to be administered by a healthcare professional, unlike oral supplements.
• Cost: Intravenous iron therapy can be more expensive than oral iron supplementation.

Composition

Each milliliter of LIKFERR100 contains 20 mg of iron (III) hydroxide sucrose complex. Additional excipients, such as sodium hydroxide and water for injection, may be present to ensure stability and pH adjustment.

Before initiating LIKFERR100 therapy, patients should undergo a thorough assessment to determine the extent of iron deficiency and to rule out contraindications. Close monitoring for adverse reactions during and after administration is essential. Always consult a healthcare professional for appropriate dosage and administration guidelines.

What is LIKFERR100?

LIKFERR100 is a parenteral iron preparation specifically formulated as a solution for intravenous (IV) injection. Each 5ml ampoule contains a precise concentration of 20mg/ml of iron (III) hydroxide sucrose complex. This complex isn’t simply elemental iron; it’s a sophisticated formulation designed for optimal absorption and minimal side effects. The iron is bound to sucrose, a sugar molecule, which facilitates its transport and distribution within the body, ultimately leading to improved iron utilization.

Unlike oral iron supplements, which can cause gastrointestinal distress in some individuals, LIKFERR100 bypasses the digestive system entirely. This direct intravenous delivery is particularly beneficial for patients with conditions that impair iron absorption through the gut or those who experience significant side effects from oral iron preparations. The solution itself is a colloidal dispersion, meaning the iron is finely divided into nanoparticles, ensuring even distribution and enhanced bioavailability.

The choice of iron (III) hydroxide sucrose complex is key to LIKFERR100’s efficacy. This specific complex is known for its relatively low incidence of adverse reactions compared to other injectable iron formulations. The careful balance between iron content and the sucrose carrier allows for rapid replenishment of iron stores without overwhelming the system. This makes LIKFERR100 a valuable therapeutic option for managing iron deficiency in a wide range of clinical situations.

Mechanism of Action

LIKFERR100’s therapeutic effect stems from its unique iron delivery system. The active ingredient, iron (III) hydroxide sucrose complex, is not directly utilized as iron in its current form. Instead, following intravenous administration, this complex undergoes a crucial dissociation process within the body’s reticuloendothelial system (RES).

The RES, primarily residing in the liver, spleen, and bone marrow, acts as a crucial processing center. Within the RES, the iron (III) hydroxide sucrose complex breaks down, releasing the iron ions. This carefully controlled release prevents the sudden influx of free iron ions, which could potentially lead to toxicity. The released iron ions are then readily available for incorporation into hemoglobin, myoglobin, and various iron-containing enzymes. This efficient uptake is crucial for addressing iron deficiency and its associated symptoms.

The sucrose component plays a vital supporting role. It not only assists in stabilizing the iron complex but also contributes to its solubility and biocompatibility. Essentially, the sucrose acts as a safe carrier, ensuring the iron is delivered to its target sites effectively and minimizes the risk of adverse effects that could arise from free iron ions circulating in the bloodstream. The entire process is designed for controlled iron replenishment, optimizing therapeutic benefits while mitigating potential risks.

Indications for Use

LIKFERR100’s primary application lies in the treatment of iron deficiency anemia. This condition, characterized by low red blood cell counts due to insufficient iron, manifests in various symptoms like fatigue, weakness, and shortness of breath. LIKFERR100 provides a rapid and effective means of replenishing iron stores, thereby alleviating these symptoms and improving overall health.

However, LIKFERR100’s utility extends beyond simple iron deficiency. It’s particularly valuable in situations where oral iron supplementation is ineffective or contraindicated. Patients with conditions affecting iron absorption in the gastrointestinal tract, such as inflammatory bowel disease, or those who experience significant gastrointestinal side effects from oral iron, may benefit greatly from LIKFERR100’s intravenous delivery system. The intravenous route ensures direct and efficient iron delivery, bypassing the potentially problematic digestive system.

Furthermore, LIKFERR100 is often the preferred choice when rapid iron repletion is crucial. In cases of acute blood loss, such as post-surgical hemorrhage, or in patients with severe iron deficiency requiring immediate intervention, LIKFERR100 offers a rapid and targeted approach to restore iron levels. Its use in such situations allows for quicker recovery and improved patient outcomes. Always consult with a healthcare professional to determine if LIKFERR100 is the appropriate treatment for your specific needs.

Administration and Dosage

The administration of LIKFERR100 requires careful attention to detail and should always be performed by a trained healthcare professional. Intravenous administration is the only approved method of delivery. The specific dosage of LIKFERR100 will vary depending on the individual patient’s needs, the severity of their iron deficiency, and their overall health status. A physician will determine the appropriate dosage regimen based on a comprehensive assessment.

While LIKFERR100 can be given as a bolus injection, meaning a single, rapid injection, it’s often administered via intravenous infusion. In this method, the solution is diluted in a compatible intravenous fluid, such as normal saline (0.9% sodium chloride), and then slowly infused over a specific period. This slower infusion rate helps to minimize the risk of adverse effects associated with rapid iron delivery. The dilution ratio and infusion rate are crucial aspects of safe and effective administration and should strictly adhere to guidelines provided by the manufacturer.

Before initiating therapy with LIKFERR100, a careful assessment of the patient’s iron status is necessary to determine the total iron requirement. This assessment may involve blood tests to measure hemoglobin levels, ferritin levels (a measure of iron stores), and other relevant parameters. Based on these assessments, the healthcare professional will calculate the total dose of LIKFERR100 needed to correct the iron deficiency. This total dose will then be divided into individual doses administered over a period of time, as directed by the physician, ensuring a safe and gradual replenishment of iron levels.

Intravenous Administration

Direct intravenous (IV) injection of LIKFERR100 is a viable method, particularly for smaller doses. This method requires a skilled healthcare professional to accurately administer the solution directly into a vein. Before injection, the solution should be visually inspected for any particulate matter or discoloration. Any abnormalities should warrant discarding the ampoule and using a new one. Strict adherence to aseptic techniques is paramount to prevent infection.

The injection site should be carefully selected and prepared to minimize discomfort and risk of complications. Post-injection, the site should be monitored for any signs of swelling, redness, or pain. The patient’s vital signs, including blood pressure and heart rate, should be closely monitored, especially during and immediately following the injection, to detect any adverse reactions promptly. Any unusual symptoms should be reported to the administering physician immediately.

While bolus injection is possible, slower administration is often preferred to reduce the likelihood of adverse reactions such as hypotension (low blood pressure). The rate of injection should be carefully controlled to ensure patient safety and comfort. In some cases, a test dose might be administered initially to assess for any immediate hypersensitivity reactions before proceeding with the full dose. Post-injection monitoring is crucial to ensure patient well-being and identify any potential complications early.

Dilution for Infusion

For larger doses or to minimize the risk of adverse reactions, LIKFERR100 is often administered via intravenous infusion after appropriate dilution. This involves adding the solution to a larger volume of compatible intravenous fluid, typically 0.9% sodium chloride solution (normal saline). The precise dilution ratio is crucial and should be determined by the healthcare professional based on the total dose of LIKFERR100 being administered and the patient’s individual needs. Improper dilution can lead to adverse effects.

The dilution process should be performed under strictly aseptic conditions to maintain the sterility of the solution. Once diluted, the solution should be thoroughly mixed to ensure uniform distribution of the iron complex. Visual inspection for any particulate matter or discoloration is necessary before administration. The diluted solution should be administered via an intravenous infusion set, with the infusion rate carefully controlled to prevent rapid delivery of iron.

The infusion rate is a critical factor influencing patient safety and tolerability. Too rapid an infusion can lead to adverse effects such as hypotension (low blood pressure) or flushing. Therefore, the healthcare professional must carefully monitor the patient’s vital signs throughout the infusion process. The infusion duration will depend on the total dose and the chosen infusion rate, but it’s typically administered over a period of time to ensure safe and effective iron delivery. Post-infusion monitoring is also recommended to identify any delayed adverse reactions.

Pros

One of the significant advantages of LIKFERR100 is its ability to provide rapid iron repletion. Unlike oral iron supplements, which are subject to variable absorption rates and potential gastrointestinal issues, LIKFERR100 delivers iron directly into the bloodstream, leading to a much faster increase in iron levels. This rapid replenishment is particularly beneficial in situations where swift correction of iron deficiency is critical, such as in cases of acute blood loss or severe anemia.

Another key advantage is its suitability for patients who cannot tolerate or benefit from oral iron therapy. Many individuals experience gastrointestinal side effects, such as nausea, constipation, or abdominal pain, when taking oral iron supplements. LIKFERR100 circumvents this problem entirely by bypassing the digestive system, making it an ideal alternative for patients with such sensitivities or those with conditions that impair gastrointestinal absorption. This significantly improves treatment adherence and patient comfort.

Furthermore, LIKFERR100 offers a high degree of bioavailability. A substantial portion of the administered iron is effectively utilized by the body for hemoglobin synthesis and other metabolic processes. This efficient utilization translates to a more effective treatment outcome, minimizing the need for high doses to achieve the desired therapeutic effect. This translates to better outcomes while potentially reducing the risk of associated side effects linked to higher cumulative iron doses.

Pros of LIKFERR100

The advantages of LIKFERR100 are numerous and contribute to its standing as a valuable treatment option for iron deficiency. Its rapid action is a key benefit; it quickly replenishes iron stores, leading to a faster alleviation of anemia symptoms such as fatigue and weakness. This speed of action is particularly advantageous in situations requiring urgent iron repletion.

Another significant advantage is its improved tolerability compared to oral iron supplements. Many patients experience significant gastrointestinal side effects from oral iron, including nausea, constipation, and abdominal discomfort. Because LIKFERR100 is administered intravenously, it bypasses the digestive system, avoiding these common problems. This improved tolerance translates to better patient compliance and overall treatment success.

Furthermore, LIKFERR100 provides enhanced bioavailability, meaning a higher proportion of the administered iron is effectively absorbed and utilized by the body. This efficient utilization translates to a more effective treatment, potentially requiring lower overall doses to achieve the desired therapeutic effect. This characteristic is important for minimizing the risk of iron overload, a potential complication associated with some iron therapies. The high bioavailability contributes to a more efficient and safer therapeutic approach.

Important Considerations

Cons

While LIKFERR100 offers numerous advantages, it’s essential to acknowledge potential drawbacks. One significant consideration is the requirement for intravenous administration. Unlike oral iron supplements, LIKFERR100 necessitates administration by a trained healthcare professional in a clinical setting. This limits its accessibility and may necessitate additional appointments, potentially impacting patient convenience and overall healthcare costs.

Another potential limitation is the risk of adverse reactions, although generally infrequent. Hypotension (low blood pressure), flushing, and allergic reactions have been reported, although their incidence is typically low. Careful monitoring during and after administration is crucial to detect and manage any adverse events promptly. Patients should be aware of these potential risks and report any unusual symptoms to their healthcare provider immediately.

Finally, the cost of LIKFERR100 can be a factor. Intravenous iron therapy is generally more expensive than oral iron supplementation. This economic consideration should be taken into account when weighing the benefits and drawbacks of LIKFERR100 against other treatment options. The higher cost often reflects the convenience, rapid action, and suitability for patients who cannot tolerate oral iron. However, the overall cost-effectiveness should be evaluated on a case-by-case basis.