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KLACID™ lyophilisate for infusion solution 500mg, 1pc

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KLACID™ 500mg Lyophilisate Buy Online

KLACID Lyophilisate for Infusion Solution: A Comprehensive Overview

KLACID, a potent antibiotic, offers a powerful solution for serious bacterial infections requiring intravenous administration. Its lyophilized form allows for convenient preparation and administration, making it a valuable tool in the fight against resistant bacteria. This overview details its key features and considerations for healthcare professionals.

KLACID lyophilisate for infusion solution contains clarithromycin, a macrolide antibiotic known for its broad-spectrum activity. This means it’s effective against a wide range of bacterial pathogens. The 500mg dosage allows for flexibility in treatment regimens, tailored to individual patient needs and the severity of the infection.

The intravenous route ensures rapid absorption and distribution of the medication throughout the body. This is particularly important in situations where oral administration is difficult or ineffective, such as severe infections or compromised gastrointestinal function. Careful adherence to recommended dosage and administration guidelines is essential for optimal therapeutic outcomes.

In the arsenal of potent antibiotics combating bacterial infections, KLACID lyophilisate for infusion solution stands out as a powerful and versatile therapeutic agent. This intravenous formulation, containing the active ingredient clarithromycin, is specifically designed to deliver rapid and effective treatment for severe or systemic infections where oral administration may be insufficient or impractical. Its lyophilized form ensures stability and ease of preparation for immediate use, a critical advantage in time-sensitive medical situations. The 500mg single-dose vial provides a flexible starting point for individualized treatment plans, allowing healthcare professionals to tailor the dosage based on patient-specific factors, such as the severity of the infection and the patient’s overall health.

Clarithromycin, a semi-synthetic macrolide antibiotic, exerts its effects by inhibiting bacterial protein synthesis. This mechanism of action disrupts the growth and reproduction of susceptible bacteria, ultimately leading to their eradication. The broad-spectrum activity of clarithromycin makes KLACID effective against a wide range of bacterial pathogens, encompassing both Gram-positive and Gram-negative organisms. This versatility is crucial in situations where the specific causative agent of an infection is yet to be identified, or where mixed infections are suspected, enabling prompt intervention while awaiting definitive diagnostic results. KLACID’s intravenous administration ensures rapid distribution of the medication throughout the body, maximizing its therapeutic impact and mitigating the risks associated with delayed treatment of severe infections.

The intravenous route of administration is particularly beneficial in situations where the patient is unable to tolerate oral medications, experiencing severe nausea or vomiting or exhibiting compromised gastrointestinal function. Furthermore, the intravenous route allows for precise control over the medication’s delivery, ensuring consistent serum concentrations and optimized therapeutic effects. The convenience of a single-dose vial simplifies the administration process, reducing the risk of errors and streamlining the workflow in busy healthcare settings. However, it’s essential to remember that KLACID, like all medications, carries the potential for side effects, underscoring the need for careful monitoring and adherence to prescribed treatment protocols.

Mechanism of Action: Targeting Bacterial Growth

At the heart of KLACID’s effectiveness lies its active ingredient, clarithromycin, a member of the macrolide antibiotic family. This powerful compound exerts its antibacterial effect by selectively binding to the 50S ribosomal subunit within bacterial cells. This precise targeting is crucial, as it prevents the bacteria from synthesizing essential proteins necessary for their survival and replication. By interfering with this fundamental process, clarithromycin effectively halts bacterial growth and, at higher concentrations, can lead to bacterial death. The specificity of this mechanism minimizes the impact on human cells, contributing to a relatively favorable safety profile compared to some broader-spectrum antibiotics.

The binding of clarithromycin to the 50S ribosomal subunit is a complex process, involving multiple interactions between the antibiotic molecule and specific amino acid residues within the ribosomal structure. This interaction physically obstructs the ribosome’s ability to translate messenger RNA (mRNA) into proteins. The resulting disruption of protein synthesis leads to a cascade of events ultimately culminating in bacterial growth inhibition. The precise nature of these interactions and the specific steps involved in protein synthesis inhibition are areas of ongoing research, providing a deeper understanding of clarithromycin’s mechanism of action and its efficacy against a wide range of bacterial pathogens.

Importantly, the effectiveness of clarithromycin is dependent on the susceptibility of the target bacteria. Not all bacterial species are equally vulnerable to its effects. Laboratory testing to determine the minimum inhibitory concentration (MIC) is often performed to assess a particular bacterial strain’s susceptibility to clarithromycin before treatment is initiated. This ensures that the chosen antibiotic will be effective against the infecting organism, optimizing treatment outcomes and minimizing the risk of treatment failure. Antibiotic resistance is an ever-growing concern, and understanding the precise mechanism of action of clarithromycin helps us to develop strategies for combating the emergence of resistant strains and maintaining the therapeutic value of this important antibiotic.

Therapeutic Uses: Indications for KLACID

KLACID’s intravenous formulation is reserved for the treatment of serious bacterial infections where oral administration is inadequate or impractical. Its broad-spectrum activity makes it a valuable option for a range of infections, but its use should always be guided by susceptibility testing and clinical judgment. The decision to use intravenous KLACID should be based on the severity of the infection, the patient’s clinical condition, and the potential benefits outweighing the risks. Empiric therapy, initiated before definitive identification of the causative organism, may be considered in life-threatening situations.

Specific indications for KLACID intravenous therapy often include infections of the lower respiratory tract, such as severe pneumonia or bronchitis, where rapid and effective antibiotic delivery is crucial. It can also be effective in treating serious skin and soft tissue infections that may not respond adequately to oral antibiotics. Furthermore, KLACID may be considered in cases of disseminated infections, where the bacteria have spread throughout the body, requiring systemic treatment with an effective intravenous antibiotic. However, the choice of antibiotic should always be guided by local antibiograms and susceptibility testing to ensure optimal efficacy.

In certain instances, KLACID may be used in the treatment of infections caused by Mycobacterium avium complex (MAC), a group of bacteria that can cause serious infections, particularly in immunocompromised individuals. Its use in such cases is often part of a broader treatment regimen, incorporating other medications to enhance its effectiveness. The specific clinical situations in which KLACID is indicated may vary based on local guidelines and the prevalence of specific antibiotic-resistant bacteria. Always consult current treatment guidelines and consider local antibiograms to guide therapeutic decisions. The severity of the infection and the patient’s overall health status should always be carefully considered when choosing a treatment strategy.

Administration and Dosage: Intravenous Infusion

KLACID lyophilisate for infusion solution is administered intravenously, and never intramuscularly or by bolus injection. This is crucial for ensuring safe and effective delivery of the medication. The lyophilized powder must be reconstituted according to the manufacturer’s instructions before administration. This typically involves adding a specified volume of a compatible diluent to the vial, resulting in a solution suitable for intravenous infusion. The resulting solution should be visually inspected for particulate matter or discoloration before administration; if either is observed, the solution should be discarded.

The recommended dosage of clarithromycin administered intravenously is typically 1 gram per day, divided into two equal doses of 500mg each. Each dose should be infused intravenously over a period of at least 60 minutes to minimize the risk of adverse reactions. Rapid administration should be avoided. The duration of treatment will vary depending on the type and severity of the infection, the patient’s response to therapy, and the infecting organism’s susceptibility to clarithromycin. Treatment should continue for a minimum of 7 days for most infections, or longer depending on clinical response.

Dosage adjustments may be necessary for patients with renal or hepatic impairment. In such cases, careful monitoring of serum drug levels and clinical response is recommended. Adjustments might involve reducing the frequency of administration or lowering the total daily dose to prevent drug accumulation and potential toxicity. Always consult the complete prescribing information for detailed instructions and dosage adjustments based on specific patient characteristics. Healthcare professionals should strictly adhere to the recommended administration guidelines, ensuring patient safety and maximizing therapeutic efficacy. Monitoring for potential side effects is also paramount during treatment.

Potential Side Effects: Managing Adverse Reactions

While KLACID is generally well-tolerated, like all medications, it can cause adverse reactions. These side effects vary in severity and frequency, ranging from mild and transient to more serious events requiring medical intervention. Careful monitoring of patients during and after treatment is essential for early detection and management of any adverse reactions. Prompt reporting of any unusual symptoms to the prescribing physician is crucial for appropriate management and minimizing potential complications.

Commonly reported side effects associated with intravenous clarithromycin administration include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. These are often mild and self-limiting, resolving spontaneously without the need for specific treatment. However, in cases of severe or persistent gastrointestinal symptoms, medical advice should be sought promptly. Infusion-site reactions, such as phlebitis or local inflammation, can also occur and may require discontinuation of the infusion or local treatment. Proper intravenous administration techniques are crucial to minimize the risk of these local reactions.

Less frequent but more serious adverse events associated with clarithromycin include changes in liver function tests, indicating potential hepatotoxicity. Monitoring liver function through routine blood tests is recommended, particularly in patients with pre-existing liver conditions or those receiving concomitant medications known to affect liver function. Allergic reactions, ranging from mild skin rashes to severe anaphylaxis, are also possible. Patients should be educated to recognize the signs and symptoms of allergic reactions and seek immediate medical attention if they occur. Careful monitoring and prompt management of any adverse reactions are paramount to ensuring patient safety and optimizing treatment outcomes.

Contraindications and Precautions: Important Considerations

KLACID, while a valuable therapeutic option, is not suitable for all patients. Known hypersensitivity to clarithromycin or other macrolide antibiotics constitutes a clear contraindication. Prior adverse reactions to clarithromycin, such as allergic reactions, should be carefully evaluated before considering its use. A history of significant liver dysfunction also necessitates caution, and in such cases, the benefits of treatment must be carefully weighed against the potential risks. Close monitoring of liver function is crucial during treatment for such patients.

Concurrent use of certain medications requires careful consideration due to potential drug interactions. For example, concomitant administration of KLACID with medications metabolized by the cytochrome P450 enzyme system (CYP3A4) may lead to altered drug concentrations, potentially increasing the risk of adverse effects or reducing therapeutic efficacy. Healthcare professionals should consult comprehensive drug interaction databases to assess potential risks and adjust dosages as necessary. This proactive approach ensures safe and effective polypharmacy, minimizing the risk of unintended consequences.

Patients with pre-existing renal or hepatic impairment require careful monitoring during treatment with KLACID. Dosage adjustments may be necessary to prevent drug accumulation and potential toxicity. Regular assessment of renal and liver function is recommended throughout the treatment course. Furthermore, caution is advised in patients with a history of cardiac arrhythmias due to the potential for prolongation of the QT interval. Electrocardiographic (ECG) monitoring might be considered in such cases, particularly when other risk factors for prolonged QT interval are present. This approach contributes to safe and effective use of KLACID in vulnerable patient populations.

Pros of KLACID

KLACID lyophilisate offers several key advantages in the treatment of serious bacterial infections. Its intravenous formulation ensures rapid absorption and distribution of the active ingredient, clarithromycin, maximizing its therapeutic impact in time-critical situations. This rapid onset of action is particularly beneficial in severe infections where prompt treatment is essential to prevent further complications or life-threatening outcomes. The intravenous route bypasses the potential limitations of oral administration, making it ideal for patients who are unable to take oral medications due to nausea, vomiting, or other gastrointestinal issues.

The lyophilized form of KLACID provides significant advantages in terms of stability and ease of preparation. The powder can be stored under appropriate conditions, ensuring its potency until reconstitution. The reconstitution process is straightforward, minimizing the time required for preparation and administration, which is critical in emergency settings. This ease of use contributes to efficient workflow in busy healthcare environments, reducing delays in treatment and enhancing overall patient care.

Furthermore, KLACID boasts a broad spectrum of activity, making it effective against a wide range of bacterial pathogens. This broad-spectrum capability is particularly valuable in cases of mixed infections or when the causative organism has not yet been definitively identified. The ability to target multiple pathogens simultaneously reduces the need for multiple antibiotics and minimizes the risk of treatment failure due to an initially incorrect diagnosis. This characteristic contributes to improved patient outcomes and reduces the overall burden of antimicrobial resistance.

A Valuable Therapeutic Option

Cons of KLACID

Despite its therapeutic benefits, KLACID, like all medications, carries potential drawbacks. One significant consideration is the risk of adverse reactions, ranging from mild gastrointestinal disturbances to more serious events such as liver damage or allergic reactions. Careful patient monitoring is essential to detect and manage these potential side effects promptly. The need for close observation and potential for interrupting treatment due to adverse effects represents a clinical challenge.

Another limitation is the potential for drug interactions. Clarithromycin’s metabolism via the cytochrome P450 enzyme system (CYP3A4) means it can interact with other drugs metabolized by the same pathway. These interactions can lead to increased or decreased drug levels, potentially altering the efficacy or safety profile of either medication. Careful consideration of concomitant medications and potential adjustments to dosage regimens are essential to mitigate these risks. This necessitates thorough review of the patient’s medication profile before initiating KLACID therapy.

Furthermore, the emergence of antibiotic resistance is a growing concern across many bacterial pathogens. While clarithromycin remains effective against many bacterial strains, the increasing prevalence of resistant organisms necessitates careful consideration of antibiotic stewardship principles. Susceptibility testing should always be performed whenever possible to guide treatment decisions and minimize the contribution to the development of antibiotic resistance. Inappropriate or prolonged use of antibiotics accelerates the selection and spread of resistant strains, diminishing the effectiveness of this important class of medications.

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