KETONAL™ ACTIVE PLUS granules for oral solution 80mg, 12pcs

KETONAL™ ACTIVE PLUS 80mg Granules Buy Online

Ketonal Active Plus: A Comprehensive Overview

Experiencing persistent pain and inflammation? Ketonal Active Plus offers a potential solution. This medication, available as granules for oral solution, provides effective relief from various conditions. Understanding its mechanism of action and potential side effects is crucial for safe and effective use.

What is Ketonal Active Plus?

Ketonal Active Plus is a non-steroidal anti-inflammatory drug (NSAID) containing the active ingredient ketoprofen, specifically as its lysine salt. It’s presented as granules designed to be dissolved in water to create an oral solution, offering a convenient method of administration. Each packet provides 80 mg of ketoprofen lysine salt, equivalent to 50 mg of ketoprofen. The formulation includes excipients such as mannitol, povidone, mint flavoring, and sodium chloride to enhance solubility and palatability.

This medication belongs to the propionic acid derivative class of NSAIDs, renowned for its analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties. The formulation’s convenient granule form allows for easy preparation and ingestion, making it suitable for various situations requiring rapid pain relief. The precise formulation aims to deliver a consistent and predictable therapeutic effect, making it a useful option for managing a range of conditions.

The granules’ formulation is designed for ease of use and rapid absorption. The mint flavoring is added to improve taste and patient compliance. It’s important to note that while Ketonal Active Plus effectively manages symptoms, it doesn’t address the underlying cause of the condition. Therefore, it is crucial to consult a healthcare professional for proper diagnosis and treatment planning. Always follow the prescribed dosage and duration to maximize efficacy and minimize potential side effects.

How Does Ketonal Active Plus Work?

Ketonal Active Plus exerts its therapeutic effects primarily through the inhibition of cyclooxygenase (COX) enzymes, COX-1 and COX-2. These enzymes are crucial in the body’s production of prostaglandins, which mediate inflammation, pain, and fever. By blocking COX enzymes, ketoprofen reduces prostaglandin synthesis, thus alleviating these symptoms.

The precise mechanism involves the non-selective inhibition of both COX-1 and COX-2 isoforms. While this broad inhibition contributes to its effectiveness in pain and inflammation management, it also increases the risk of gastrointestinal side effects associated with COX-1 inhibition. The lysine salt form of ketoprofen in Ketonal Active Plus is designed to improve its solubility and absorption, facilitating faster onset of action compared to some other ketoprofen formulations.

Following oral administration, ketoprofen is rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours. The drug is extensively metabolized in the liver and excreted primarily via the kidneys. Its relatively short half-life necessitates regular dosing to maintain therapeutic levels. The precise pharmacokinetic profile can be influenced by factors such as hepatic and renal function, age, and concomitant medications. Therefore, careful consideration of these factors is necessary when prescribing Ketonal Active Plus.

Uses of Ketonal Active Plus

Ketonal Active Plus is indicated for the short-term treatment of various conditions characterized by pain and inflammation. Its analgesic and anti-inflammatory properties make it suitable for managing a range of symptoms. Always consult a healthcare professional for diagnosis and to ensure appropriate use.

Common applications include the symptomatic relief of musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, and other inflammatory joint conditions. The drug effectively reduces pain and stiffness associated with these conditions, improving mobility and quality of life. It’s also useful for managing acute pain, such as that following surgery or trauma, providing temporary relief while the underlying condition heals.

Beyond musculoskeletal conditions, Ketonal Active Plus can be used to treat certain types of headaches and migraines, offering symptomatic relief from pain and associated inflammation. Additionally, it may be prescribed for the management of dysmenorrhea (menstrual cramps), providing temporary relief from the associated pain. It’s crucial to remember that Ketonal Active Plus addresses symptoms, not the underlying cause, and should be used as directed by a physician. Self-medication is strongly discouraged.

Specific applications may also include the treatment of postoperative pain and dental pain, offering quick and effective relief. However, the suitability of Ketonal Active Plus for these conditions should always be determined by a healthcare professional, taking into account individual patient factors and potential drug interactions. Remember that this medication should only be used for short-term symptomatic relief under the guidance of a physician.

Dosage and Administration

Ketonal Active Plus is administered orally. The granules must be dissolved completely in a suitable amount of water before ingestion. The solution should be taken with or without food, depending on individual tolerance and physician recommendation. Never exceed the recommended dosage.

For adults, the typical dosage is one packet (80 mg ketoprofen lysine salt) up to three times daily. However, individual dosages may vary based on the severity of the condition and the patient’s response to treatment. Always follow the specific instructions provided by your doctor or pharmacist. Adjustments to the dosage may be necessary for patients with impaired renal or hepatic function.

Children aged 6 to 14 years may be prescribed a lower dosage, determined by the physician considering the child’s weight and clinical condition. For children aged 14 to 18 years, the dosage may be the same as for adults. However, pediatric use requires careful monitoring and should always be under the supervision of a pediatrician or healthcare professional. Precise dosage regimens should be determined on a case-by-case basis, tailored to the individual patient’s needs.

The duration of treatment should be as short as possible to alleviate symptoms. Prolonged use may increase the risk of adverse effects. It is crucial to consult a healthcare professional if symptoms persist or worsen during treatment. Never alter the dosage without explicit guidance from a doctor or pharmacist. Always carefully read the patient information leaflet provided with the medication for detailed instructions and precautions.

Pros of Ketonal Active Plus

Ketonal Active Plus offers several advantages, making it a viable option for managing pain and inflammation in specific situations. Its rapid onset of action provides relatively quick relief from symptoms, which is particularly beneficial for acute pain episodes. The convenient granule formulation allows for easy preparation and administration, enhancing patient compliance, especially for those who may struggle with swallowing tablets.

The formulation’s palatability, due to the addition of mint flavoring, improves patient acceptance and reduces the chances of non-compliance. This is particularly important for children or patients who are sensitive to the taste of medication. Moreover, Ketonal Active Plus is available in a dosage form suitable for both adult and pediatric patients (under strict medical supervision), broadening its applicability. The short treatment duration, aiming for symptom relief rather than long-term management, minimizes potential long-term side effects.

Compared to some other NSAIDs, Ketonal Active Plus may offer a favorable efficacy-to-side-effect profile for certain individuals and specific conditions. However, it’s crucial to remember that this is a subjective assessment, and individual responses may vary significantly. The drug’s relatively short half-life, while requiring more frequent dosing, also means that the body clears it more quickly, reducing the potential for drug accumulation and associated risks. Always consult with a healthcare professional to assess the suitability of Ketonal Active Plus in your specific case.

Cons of Ketonal Active Plus

While Ketonal Active Plus offers effective pain and inflammation relief, potential drawbacks necessitate careful consideration. As a non-selective NSAID, it inhibits both COX-1 and COX-2 enzymes, increasing the risk of gastrointestinal side effects such as nausea, heartburn, abdominal pain, and, in rare cases, more serious complications like ulcers or bleeding. This risk is heightened in patients with pre-existing gastrointestinal conditions.

The medication’s potential to affect renal function is another significant concern, especially with prolonged use or in patients with pre-existing kidney problems. Monitoring of kidney function may be necessary, particularly in vulnerable populations like the elderly or those with underlying renal disease. Furthermore, Ketonal Active Plus, like other NSAIDs, can increase the risk of cardiovascular events, including heart attack and stroke, particularly with high doses or prolonged use. This risk must be carefully weighed against the potential benefits.

Allergic reactions, ranging from mild skin rashes to more severe anaphylaxis, are possible, though relatively uncommon. Patients with a history of allergies to NSAIDs or aspirin should exercise particular caution. The necessity for regular dosing due to its relatively short half-life can be inconvenient for some patients. Finally, because Ketonal Active Plus masks symptoms of infection, it is crucial to consult a doctor if symptoms persist or worsen, as this could delay diagnosis and treatment of a potentially serious infection.

Precautions and Side Effects

Before starting Ketonal Active Plus, inform your doctor about any pre-existing medical conditions, particularly those affecting the heart, kidneys, liver, or gastrointestinal tract. Individuals with a history of ulcers, bleeding disorders, or allergies to NSAIDs should exercise special caution. Concomitant use with certain medications may necessitate dosage adjustments or require careful monitoring. Always inform your physician about all medications you are taking.

Common side effects can include gastrointestinal disturbances such as nausea, heartburn, indigestion, and abdominal pain. Less frequent but more serious side effects may involve gastrointestinal bleeding or ulceration. Cardiovascular risks, including hypertension and increased risk of heart attack or stroke, are possible, particularly with prolonged use or high doses. Renal impairment, manifested by changes in urine output or elevated creatinine levels, is also a potential concern.

Neurological side effects such as dizziness, headache, and drowsiness can occur, potentially affecting the ability to drive or operate machinery. Allergic reactions, ranging from skin rashes to anaphylaxis, are possible, though rare. Patients experiencing any unusual or concerning symptoms should discontinue use and seek immediate medical attention. Regular monitoring of kidney and liver function may be advisable, particularly during long-term treatment. The potential for interactions with other medications highlights the importance of complete disclosure of all medications to your healthcare provider.

Specific considerations apply to elderly patients and individuals with impaired renal or hepatic function. Dosage adjustments may be necessary, and close monitoring is often recommended. During pregnancy, especially beyond the 20th week, and breastfeeding, this medication should be avoided unless deemed absolutely necessary by a physician. Always inform your physician of your pregnancy status or breastfeeding plans. The use of Ketonal Active Plus should always be under the guidance of a qualified healthcare professional. Patient education concerning potential side effects and precautions is crucial for safe and effective use.

Contraindications

Ketonal Active Plus is contraindicated in several situations, emphasizing the importance of thorough medical evaluation before initiating treatment. Patients with a known hypersensitivity or allergy to ketoprofen, other NSAIDs, or any of the excipients present in the formulation should strictly avoid this medication. A history of allergic reactions, such as asthma, urticaria, or rhinitis, triggered by aspirin or other NSAIDs, constitutes a significant contraindication. The risk of severe allergic reactions necessitates careful consideration.

Individuals with active peptic ulcer disease or a history of gastrointestinal bleeding should not use Ketonal Active Plus. The medication’s potential to exacerbate these conditions makes it unsuitable for patients with such pre-existing vulnerabilities. Severe hepatic or renal impairment also contraindicates its use. The medication is extensively metabolized by the liver and excreted by the kidneys, and therefore impaired function of either organ significantly increases the risk of adverse events. This underscores the need for careful assessment of organ function prior to prescribing.

Pregnancy, particularly beyond the 20th week of gestation, represents a contraindication. The potential risks to both mother and fetus outweigh the potential benefits. Breastfeeding is also a contraindication, as ketoprofen may be excreted into breast milk, potentially posing risks to the nursing infant. Children under the age of 6 years should not receive Ketonal Active Plus due to the lack of sufficient safety and efficacy data in this age group. The use of this medication should always be under the direction of a physician who can assess the individual patient’s risk profile and contraindications.

Interactions with Other Medications

Ketonal Active Plus can interact with various medications, potentially altering their efficacy or increasing the risk of adverse effects. Concurrent use with other NSAIDs should be avoided due to the increased risk of gastrointestinal bleeding and renal toxicity. Combining Ketonal Active Plus with anticoagulants (blood thinners) or antiplatelet agents (such as aspirin) can significantly elevate the risk of bleeding. Careful monitoring and potential dosage adjustments are necessary under such circumstances.

The drug’s interaction with lithium necessitates close monitoring of lithium levels, as ketoprofen can increase lithium concentrations in the blood, potentially leading to lithium toxicity. Similarly, concomitant use with ACE inhibitors or angiotensin receptor blockers (ARBs) may affect renal function, requiring careful monitoring of kidney parameters. Ketonal Active Plus can also interact with diuretics (water pills), potentially reducing their effectiveness and increasing the risk of kidney problems. Therefore, careful consideration should be given when combining Ketonal Active Plus with these medications.

Methotrexate’s toxicity can be heightened by Ketonal Active Plus, requiring careful consideration and potential dosage adjustments of methotrexate to mitigate this risk. Concurrent use with cyclosporine or tacrolimus increases the risk of nephrotoxicity (kidney damage). Furthermore, the drug may interfere with the efficacy of certain drugs used to treat hypertension or heart failure. Always inform your doctor about all medications, including over-the-counter drugs and herbal supplements, to minimize the risk of adverse interactions. This ensures safer and more effective treatment outcomes. Failure to disclose medications can have serious consequences.

Additional Considerations

Ketonal Active Plus, while effective for short-term pain and inflammation management, should not be considered a long-term solution. It’s crucial to address the underlying cause of the condition, and Ketonal Active Plus should be viewed as a tool for symptomatic relief, not a cure. Prolonged use should be carefully considered and only undertaken under strict medical supervision, given the potential for increased risk of adverse effects.

Patients should be aware of the potential for Ketonal Active Plus to mask symptoms of infection, potentially delaying diagnosis and treatment. If symptoms of infection persist or worsen while taking this medication, immediate medical attention is crucial. The drug can also affect platelet function, increasing the risk of bleeding. Individuals undergoing surgical procedures or those with bleeding disorders should discuss this risk with their doctor before starting treatment.

The effect of Ketonal Active Plus on fertility is another important consideration. Women planning pregnancy or experiencing fertility issues should discuss the potential risks with their physician before using this medication. The presence of mannitol in the formulation may have a mild laxative effect in some individuals. Finally, this medication contains negligible amounts of sodium, making it suitable for patients on low-sodium diets. Always follow your doctor’s instructions and heed all warnings and precautions listed in the patient information leaflet.