DIPEPTIVEN™ infusion concentrate solution 20% (100ml), vials 10pcs

DIPEPTIVEN™ 20% Solution 100ml Buy Online

Dipeptiven Infusion Concentrate Solution: A Comprehensive Overview

Dipeptiven, a crucial component in parenteral nutrition, plays a vital role in supporting patients with increased glutamine demands. This concentrated solution offers a targeted approach to nutritional management, addressing specific metabolic needs often overlooked in standard nutritional therapies.

The 20% concentration allows for precise and efficient administration, tailoring the dosage to individual patient requirements. Its formulation as an infusion concentrate ensures compatibility with various infusion solutions, maximizing flexibility in clinical settings. This adaptability makes it suitable for a wide range of patient populations.

Dipeptiven’s unique formulation contributes to improved nitrogen balance and protein metabolism. It acts as a key building block for cellular processes and aids in the body’s natural recovery mechanisms. The solution is designed for intravenous administration, ensuring rapid uptake and utilization by the body.

Understanding Dipeptiven

What is Dipeptiven?

Dipeptiven is a sterile, non-pyrogenic infusion concentrate solution containing N(2)-L-alanyl-L-glutamine. This dipeptide is a crucial source of glutamine, an essential amino acid playing a vital role in cellular metabolism and immune function. Its administration is particularly beneficial in situations where the body’s glutamine requirements are significantly elevated.

Mechanism of Action

Dipeptiven’s mechanism of action centers around the provision of readily available glutamine. Glutamine is a conditionally essential amino acid, meaning its synthesis may be insufficient during periods of stress or illness. By supplementing glutamine levels, Dipeptiven helps to support protein synthesis, reduce muscle breakdown (catabolism), and improve the body’s ability to fight infection. It aids in maintaining intestinal integrity and supports overall metabolic homeostasis.

The dipeptide form of glutamine in Dipeptiven enhances its stability and bioavailability compared to free glutamine, leading to more efficient utilization by cells. This superior delivery system ensures a targeted approach to nutritional support. The solution’s intravenous administration enables rapid delivery to tissues and cells in need, promoting a swift response to nutritional deficiencies.

What is Dipeptiven?

Dipeptiven is a specialized parenteral nutrition solution designed to address critical nutritional deficiencies, particularly in patients experiencing heightened glutamine demands. It’s a sterile, non-pyrogenic concentrate, meaning it’s free from harmful bacteria and fever-inducing substances. This ensures safe and effective intravenous administration. The solution is presented as a 20% concentrate, providing flexibility in dosage adjustments to meet individual patient needs.

The core component of Dipeptiven is N(2)-L-alanyl-L-glutamine, a dipeptide form of glutamine. This dipeptide is a more stable and bioavailable form of glutamine than free glutamine, ensuring efficient absorption and utilization by the body. This enhanced bioavailability is crucial for patients whose bodies struggle to produce sufficient glutamine to meet their metabolic demands. The formulation is designed for infusion into central veins after dilution with a compatible intravenous fluid, enabling seamless integration into existing parenteral nutrition regimens.

Mechanism of Action

Dipeptiven’s primary mechanism involves the delivery of N(2)-L-alanyl-L-glutamine, a dipeptide readily metabolized into glutamine, a conditionally essential amino acid. This efficient delivery bypasses potential metabolic limitations associated with administering free glutamine, ensuring optimal utilization. Glutamine plays a crucial role in various cellular processes, acting as a primary fuel source for rapidly dividing cells, such as those in the gut and immune system.

By providing a readily available source of glutamine, Dipeptiven supports protein synthesis and reduces muscle wasting, commonly observed in catabolic states. It also helps maintain intestinal barrier function, protecting against gut permeability and reducing the risk of infections. This protective effect is particularly significant in critically ill patients or those undergoing major surgery. Furthermore, its contribution to immune function makes it valuable in supporting recovery from illness or injury.

The dipeptide form of glutamine offers enhanced stability and reduces the potential for degradation during storage and administration, contributing to its overall efficacy. This stability is paramount in ensuring that the intended therapeutic benefits are consistently delivered to the patient. The intravenous administration method ensures rapid and efficient distribution throughout the body, maximizing the therapeutic effects of the supplement.

Clinical Applications of Dipeptiven

Patient Populations

Dipeptiven finds application in various clinical settings where patients exhibit increased glutamine needs. Critically ill patients, those undergoing major surgery, or individuals suffering from severe trauma often experience heightened glutamine demands. These situations frequently lead to compromised immune function and impaired protein synthesis, making supplemental glutamine crucial for recovery. Patients with severe burns or extensive wounds also benefit from Dipeptiven’s support of tissue repair and immune function.

Administration

Dipeptiven is administered intravenously, typically as part of a comprehensive parenteral nutrition regimen. The concentrate must be diluted with a compatible intravenous solution before administration. The precise dilution and infusion rate are determined by the patient’s individual needs and overall clinical condition. Close monitoring of the patient’s response to therapy is crucial to ensure optimal efficacy and safety. Careful attention to proper aseptic techniques during preparation and administration is essential to minimize the risk of infection.

Patient Populations

Dipeptiven’s use is primarily indicated for patients experiencing heightened glutamine requirements, a condition often associated with critical illness. This includes individuals suffering from severe trauma, undergoing major surgical procedures, or battling life-threatening infections. The enhanced glutamine supply helps to mitigate the negative consequences of catabolism, supporting the body’s natural healing processes. These patients often exhibit impaired protein synthesis and compromised immune function, making supplemental glutamine a valuable therapeutic intervention.

Patients recovering from extensive burns or those with large, non-healing wounds represent another significant patient population. In these cases, glutamine plays a vital role in supporting tissue repair and regeneration. Its contribution to immune function is also crucial, as these patients are highly susceptible to infections. The use of Dipeptiven in these scenarios aims to improve overall outcomes, reduce complications, and enhance the healing process. Furthermore, individuals with certain gastrointestinal disorders might benefit from Dipeptiven’s ability to support intestinal integrity and reduce inflammation.

Administration

Dipeptiven, a 20% concentrate, requires dilution before intravenous administration. This dilution is crucial to achieve the appropriate osmolarity and prevent potential adverse effects associated with rapid infusion of a highly concentrated solution. The choice of diluent should ensure compatibility with Dipeptiven and the overall parenteral nutrition regimen. Strict adherence to aseptic techniques during preparation and administration is paramount to minimize the risk of infection.

The rate of infusion is determined on a case-by-case basis, considering the patient’s clinical status and overall fluid balance. Close monitoring of the patient’s response to the infusion, including vital signs and laboratory parameters, is essential. Any adverse reactions should be promptly reported and addressed. This careful approach ensures safe and effective administration, maximizing the therapeutic benefits while minimizing potential risks. The specific protocols for preparation and administration should always follow guidelines established by healthcare professionals.

Central venous access is typically required for Dipeptiven administration due to its concentration. This ensures efficient distribution throughout the circulatory system and reduces the risk of local irritation or inflammation at the injection site. Peripheral venous administration might be considered only under specific circumstances and with careful monitoring. The healthcare provider will determine the appropriate route and rate of administration based on the individual patient’s needs and clinical assessment.

Dosage and Considerations

Dosage Regimen

Dipeptiven dosage is highly individualized and depends on several factors, including the patient’s nutritional status, clinical condition, and overall metabolic needs. A typical dosage range might be 0.3 to 0.5 grams of N(2)-L-alanyl-L-glutamine per kilogram of body weight per day. However, this is merely a guideline, and the precise dosage should be determined by a healthcare professional based on a comprehensive assessment of the patient’s specific requirements. Close monitoring of the patient’s response is crucial to optimize the dosage and ensure therapeutic efficacy.

The administration of Dipeptiven is typically integrated into a broader parenteral nutrition plan, ensuring the patient receives a balanced supply of essential nutrients. The dosage might need adjustment depending on the patient’s tolerance and response to the treatment. Regular monitoring of laboratory values, such as blood urea nitrogen and creatinine levels, is important to assess the effectiveness of the therapy and to identify any potential adverse effects. Healthcare providers should carefully tailor the dosage to individual circumstances, considering factors like the patient’s age, weight, and underlying medical conditions.

It’s crucial to remember that Dipeptiven is a concentrate and must be appropriately diluted before intravenous administration. The final concentration of the diluted solution should be carefully calculated to avoid potential complications associated with rapid infusion of a hyperosmolar solution. Healthcare professionals should strictly adhere to established guidelines and protocols for preparing and administering Dipeptiven to maintain patient safety and treatment effectiveness. Regular monitoring of the patient’s fluid balance and electrolyte levels is also recommended during treatment.

Dosage Regimen

Dipeptiven’s dosage is not standardized and requires careful individualization based on the patient’s specific needs and clinical condition. Healthcare professionals typically consider factors such as the patient’s weight, overall nutritional status, and the severity of their illness when determining the appropriate dosage. While a general range might be suggested, the final dosage is always determined through a thorough clinical assessment and is often adjusted throughout the course of treatment.

The recommended daily dose is usually expressed as a range of milligrams or grams of N(2)-L-alanyl-L-glutamine per kilogram of body weight. This dosage may be administered as a continuous infusion or intermittent infusions over a defined period. The method of administration and the infusion rate are determined by the healthcare provider, taking into account the patient’s overall fluid balance and tolerance. Regular monitoring of the patient’s response to the treatment is essential to ensure efficacy and safety.

It is crucial to remember that Dipeptiven is a concentrate and must be diluted before administration. The final concentration of the diluted solution should fall within a safe and clinically appropriate range to prevent potential adverse effects from rapid infusion of a hyperosmolar solution. The healthcare provider should carefully consider the patient’s fluid balance, renal function, and other relevant clinical factors when determining the appropriate dilution and infusion rate. Close monitoring of the patient is necessary throughout the treatment course.

Pros of Dipeptiven

Advantages

Dipeptiven offers several key advantages in managing nutritional deficiencies, particularly in critically ill patients. Its use of the dipeptide form of glutamine, N(2)-L-alanyl-L-glutamine, offers enhanced stability and bioavailability compared to free glutamine. This translates to more efficient uptake and utilization by cells, maximizing the therapeutic benefits. The improved stability also means less degradation during storage and administration, ensuring consistent delivery of the active compound.

The concentrated formulation allows for precise dosage adjustments, tailoring the therapy to individual patient needs. This flexibility is crucial in managing the varying glutamine requirements across diverse patient populations. Furthermore, Dipeptiven’s compatibility with various intravenous solutions simplifies its integration into existing parenteral nutrition regimens, streamlining the overall treatment process for healthcare providers. This ease of integration contributes to improved efficiency and reduces the complexity of administering multiple intravenous solutions.

Dipeptiven’s contribution to improved nitrogen balance and protein metabolism is significant. By supporting protein synthesis and reducing muscle breakdown, it helps patients maintain their lean body mass and promotes faster recovery. This is particularly important in critically ill patients who are often in a catabolic state. The positive impact on intestinal integrity also protects against gut-related complications, which are frequently observed in critically ill individuals. This multifaceted approach to nutritional support significantly contributes to improved patient outcomes.

Limitations

Advantages

Dipeptiven’s superior bioavailability, stemming from its dipeptide formulation, ensures efficient cellular uptake and utilization of glutamine. This enhanced delivery mechanism translates to improved efficacy in supporting protein synthesis and reducing muscle breakdown, particularly beneficial in catabolic states often associated with critical illness. The readily available glutamine helps to replenish depleted stores, accelerating the body’s natural recovery processes.

The concentrated nature of Dipeptiven allows for precise dosage adjustments, enabling healthcare professionals to tailor treatment to individual patient needs. This flexibility is crucial in managing the variable glutamine requirements observed across different patient populations and disease severities. The solution’s compatibility with various intravenous fluids simplifies integration into existing parenteral nutrition plans, streamlining the overall treatment process.

Beyond its direct impact on protein metabolism, Dipeptiven contributes to improved gut health and immune function. By supporting the integrity of the intestinal lining, it reduces the risk of gut-related complications, a frequent concern in critically ill patients. This positive influence on the gut barrier and immune response contributes to improved overall patient outcomes and a reduced risk of infections. The combination of these benefits positions Dipeptiven as a valuable tool in supporting patients with heightened glutamine demands.