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CLARITHROMYCIN tablets 500mg, 10pcs

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CLARITHROMYCIN 500mg 10 Tablets Pack Buy Online

Clarithromycin 500mg Tablets: A Comprehensive Overview

Seeking effective treatment for bacterial infections? Clarithromycin, a macrolide antibiotic, offers a powerful solution. This comprehensive overview explores its properties, uses, and potential side effects.

Clarithromycin 500mg tablets are a common formulation of this versatile medication. Its broad-spectrum activity targets a wide range of bacterial pathogens, making it suitable for various infections. The 500mg strength provides a potent dose for effective treatment.

Understanding its mechanism of action is crucial. Clarithromycin works by inhibiting bacterial protein synthesis, ultimately preventing bacterial growth and leading to their elimination from the body. This powerful action is key to its effectiveness against various infections.

The precise dosage and administration will depend on the specific infection and patient factors. Always follow your doctor’s instructions carefully and do not deviate from the prescribed regimen. Improper use can compromise treatment efficacy.

What is Clarithromycin?

Clarithromycin is a semi-synthetic macrolide antibiotic, effective against a wide range of bacteria. It is frequently prescribed for respiratory, skin, and other infections.

Clarithromycin binds to the 50S ribosomal subunit of bacteria, thus inhibiting protein synthesis. This leads to bacterial cell death or inhibits their growth.

Clarithromycin is used to treat various infections, including those of the respiratory tract (pneumonia, bronchitis), skin and soft tissues, and infections caused by Helicobacter pylori.

Dosage varies depending on the infection and patient factors. Always follow your physician’s instructions precisely. Standard dosages typically involve oral administration.

Clarithromycin is well-absorbed after oral administration. It is metabolized in the liver, and excreted through both urine and feces. Plasma concentrations vary depending on dosage.

  • Effective against a broad spectrum of bacteria.
  • Available in various formulations.
  • Generally well-tolerated.
  • Potential for side effects.
  • Drug interactions are possible.
  • Not effective against all bacterial infections.

Side Effects

Common side effects include nausea, diarrhea, vomiting, and abdominal pain. More serious but less frequent side effects include liver problems and allergic reactions. Consult your physician for any concerns.

Clarithromycin should be used cautiously in patients with liver or kidney disease. It is contraindicated in those with known allergies to macrolide antibiotics.

What is Clarithromycin?

Clarithromycin is a powerful antibiotic belonging to the macrolide class of drugs. It’s a semi-synthetic derivative of erythromycin, meaning it’s created in a laboratory based on the structure of the naturally occurring antibiotic. This modification often enhances its effectiveness and properties compared to its parent compound. Its mechanism of action involves targeting bacterial ribosomes, the cellular machinery responsible for protein synthesis. By interfering with this process, clarithromycin effectively halts bacterial growth and replication.

This makes it a valuable tool in combating a broad range of bacterial infections. Importantly, clarithromycin demonstrates activity against both gram-positive and gram-negative bacteria, meaning its effectiveness spans several types of microorganisms. Its efficacy extends beyond simply inhibiting bacterial growth; in certain circumstances, it can exhibit bactericidal properties, directly killing bacterial cells. This dual action contributes to its robust therapeutic profile.

The versatility of clarithromycin is further highlighted by its ability to penetrate various tissues and fluids within the body. This characteristic allows it to reach infection sites effectively, even those that are difficult for other antibiotics to access. This enhanced tissue penetration contributes to its efficacy in treating a variety of infections. Furthermore, clarithromycin’s effectiveness against intracellular bacteria, those that reside within host cells, sets it apart from some other antibiotics.

Due to these properties, clarithromycin finds application in treating a wide spectrum of infections, ranging from respiratory illnesses like pneumonia and bronchitis to skin infections and infections of the gastrointestinal tract. Its use is often guided by culture and sensitivity testing to ensure optimal efficacy against the specific bacterial pathogen involved. The choice of clarithromycin, and its dosage, should always be determined in consultation with a healthcare professional.

Mechanism of Action

Clarithromycin’s effectiveness stems from its unique interaction with bacterial cells. Unlike some antibiotics that disrupt cell walls, clarithromycin targets the protein synthesis machinery within bacteria. Specifically, it binds to the 50S ribosomal subunit, a crucial component involved in translating genetic information into functional proteins. This binding action effectively blocks this vital process, preventing the bacteria from producing the essential proteins necessary for survival and replication.

The inhibition of protein synthesis is a highly effective strategy for combating bacterial infections. By disrupting this fundamental cellular function, clarithromycin exerts its bacteriostatic effect, halting bacterial growth. In higher concentrations or against susceptible bacteria, this effect can transition to bactericidal, resulting in the direct killing of the bacterial cells. The precise mechanism by which this transition occurs is complex and influenced by various factors, including the bacterial species, antibiotic concentration, and the overall environment.

Furthermore, the interaction of clarithromycin with the 50S ribosomal subunit is highly specific, minimizing the risk of interference with human cellular processes. Human cells lack the bacterial 50S ribosomal subunit, hence the selective toxicity of the antibiotic. This selectivity reduces the likelihood of undesirable side effects associated with the disruption of human cell functions. This characteristic is a key aspect of clarithromycin’s safety profile.

The efficiency of clarithromycin’s mechanism of action is further enhanced by its ability to reach and effectively concentrate within various tissues and fluids throughout the body. This broad distribution allows the antibiotic to target infections at various sites within the body, including those affecting the lungs, skin, and gastrointestinal tract. The ability to reach intracellular bacteria, those residing within host cells, represents a significant advantage over some other antibiotic classes.

Therapeutic Uses

Clarithromycin’s broad-spectrum activity makes it a valuable treatment option for a wide array of bacterial infections. Its effectiveness against a variety of both gram-positive and gram-negative bacteria is particularly noteworthy. This versatility allows it to be deployed against a range of infections affecting various parts of the body.

Respiratory tract infections are a common target for clarithromycin therapy. Conditions such as pneumonia, bronchitis, and sinusitis often respond well to treatment. Its ability to reach and effectively target bacteria within the lungs makes it a suitable choice for these respiratory infections. The specific bacteria involved often dictate the choice of antibiotic, and culture and sensitivity testing are key to ensuring effective therapy.

Beyond the respiratory system, clarithromycin effectively treats skin and soft tissue infections. Conditions ranging from uncomplicated cellulitis to more localized infections can benefit from its use. Its ability to penetrate tissues makes it suitable for addressing infections that may be deeper within the skin layers. Again, appropriate testing to identify the infecting organism is critical for treatment success.

Moreover, clarithromycin plays a significant role in the eradication of Helicobacter pylori, a bacterium strongly linked to peptic ulcers. It’s typically used in combination with other medications as part of a comprehensive treatment regimen. This multi-drug approach is crucial for achieving high eradication rates and preventing recurrence of infection. The combination therapy often includes a proton pump inhibitor to reduce stomach acid production, creating a more favorable environment for the antibiotic to work.

Finally, clarithromycin finds application in the treatment of certain mycobacterial infections, particularly in immunocompromised individuals. Conditions caused by Mycobacterium avium complex (MAC) often require long-term treatment with clarithromycin, often in combination with other agents. The specific treatment strategy depends on the patient’s immune status and the severity of the infection. This highlights the importance of individualized treatment plans guided by expert medical advice.

Dosage and Administration

Clarithromycin is typically administered orally, with the specific dosage regimen depending heavily on the type and severity of the infection being treated, as well as the patient’s individual characteristics, such as age, weight, and kidney or liver function. It’s crucial to emphasize that the information provided here is for general understanding only, and should not be used to self-prescribe or alter a prescribed dosage. Always follow the instructions provided by your healthcare professional.

For adults, common dosages range from 250mg to 500mg, taken twice daily. The frequency of administration (twice daily versus once daily) and the duration of treatment (typically 7 to 14 days) are determined by the treating physician based on the individual’s condition. For certain infections, such as those caused by Helicobacter pylori, a higher dosage or a longer duration may be necessary, often in combination with other medications.

In children, the dosage is typically calculated based on body weight, usually expressed as milligrams per kilogram (mg/kg) per day. The precise dosage and administration schedule must be determined by a pediatrician or other qualified healthcare professional. The medication is usually administered in a liquid suspension form for children who cannot swallow tablets. Always follow pediatric dosing guidelines carefully, as exceeding the recommended amount can lead to adverse effects.

Patients with impaired kidney or liver function often require dosage adjustments to prevent accumulation of the medication in the body and to minimize the risk of side effects. Individuals with these conditions should always inform their physician of their medical history prior to starting treatment. The physician will determine the appropriate dosage based on the specific condition and the results of any necessary laboratory tests.

Furthermore, it is essential to take clarithromycin as directed by your doctor, even if you begin to feel better before the prescribed course is completed. Stopping the treatment early can lead to incomplete eradication of the infection, potentially resulting in recurrence or the development of antibiotic resistance. Completing the entire course is necessary for optimal therapeutic success.

Pharmacokinetics

Understanding the pharmacokinetic profile of clarithromycin is crucial for optimizing its therapeutic use. After oral administration, clarithromycin is readily absorbed from the gastrointestinal tract, although the presence of food can slightly delay absorption. The extent of absorption, however, isn’t significantly affected by food intake, ensuring consistent therapeutic levels regardless of meal timing. This makes it convenient for patients, as strict adherence to meal timing isn’t generally required.

Once absorbed, clarithromycin distributes widely throughout the body, reaching therapeutic concentrations in various tissues and organs, including the lungs, skin, and other infection sites. This widespread distribution contributes to its effectiveness against infections in multiple locations. The drug’s ability to penetrate into cells also aids in combating intracellular bacteria, those that reside within host cells, thus expanding its therapeutic reach.

Clarithromycin undergoes significant hepatic metabolism, primarily through the cytochrome P450 enzyme system. This metabolic pathway produces 14-hydroxyclarithromycin, a major metabolite which also possesses antimicrobial activity. This metabolite contributes significantly to the overall antimicrobial effect, extending the spectrum of activity against some bacteria. The interplay between the parent drug and its active metabolite contributes to a prolonged therapeutic effect.

Elimination of clarithromycin occurs primarily through both renal and biliary excretion. A portion of the drug is excreted unchanged in the urine, while another portion is eliminated through the bile and feces. This dual elimination pathway ensures efficient clearance from the body. However, patients with impaired renal or hepatic function may require dosage adjustments to prevent drug accumulation, thereby minimizing the risk of adverse effects. Such adjustments are crucial for patient safety and treatment efficacy.

The pharmacokinetic parameters, such as peak plasma concentration (Cmax), time to reach peak concentration (Tmax), and elimination half-life (t1/2), can vary depending on the dosage, route of administration, and individual patient characteristics, such as age, renal function, and hepatic function. These variations underscore the need for individualized dosage adjustments as guided by a healthcare professional, ensuring optimal therapeutic outcomes while minimizing potential adverse events.

Pros

Clarithromycin offers several advantages as an antibiotic treatment option. Its broad-spectrum activity is a significant benefit, allowing it to target a wide range of bacterial pathogens responsible for various infections. This broad coverage reduces the need for extensive testing to identify the specific bacteria causing the infection, streamlining treatment initiation.

Another key advantage is its excellent tissue penetration. This characteristic allows clarithromycin to reach infection sites effectively, even those that are difficult for other antibiotics to penetrate. This enhanced tissue penetration contributes to its efficacy in treating a variety of infections, particularly those affecting deeper tissues or intracellular bacteria.

Furthermore, clarithromycin is generally well-tolerated by most patients. While side effects can occur, they are often mild and manageable. This favorable tolerability profile makes it a suitable choice for many patients, particularly those who may have experienced adverse reactions to other antibiotics. However, individual responses can vary, and careful monitoring is always advisable.

The availability of clarithromycin in various formulations further enhances its practicality. It is available in both tablet and suspension forms, catering to diverse patient needs and preferences. This range of formulations allows for flexibility in treatment based on individual patient factors, such as age and ability to swallow tablets. The flexibility in administration improves patient compliance and overall treatment success.

Finally, clarithromycin’s effectiveness against certain intracellular bacteria is a significant advantage. Its ability to penetrate host cells and target pathogens within them is a critical aspect of its therapeutic efficacy. This capability makes it suitable for treating infections involving bacteria that reside within cells, such as Mycoplasma pneumoniae, which causes atypical pneumonia.

Precautions and Contraindications

Cons

Despite its numerous benefits, clarithromycin, like all medications, carries potential drawbacks. One significant consideration is the possibility of side effects. While many are mild and transient, such as nausea, diarrhea, and abdominal discomfort, more serious adverse reactions, though less common, can occur. These include liver damage and allergic reactions, necessitating close monitoring and prompt medical attention if symptoms arise.

Another concern involves drug interactions. Clarithromycin’s metabolism through the cytochrome P450 enzyme system means it can interact with other medications metabolized via the same pathway. These interactions can lead to altered drug levels, potentially increasing the risk of side effects or reducing the effectiveness of either medication. It’s crucial for patients to inform their physician of all medications, supplements, and herbal remedies they are taking to avoid potentially harmful interactions.

The development of antibiotic resistance is a growing concern with widespread antibiotic use. Prolonged or inappropriate use of clarithromycin can contribute to the emergence of resistant bacterial strains, rendering the antibiotic ineffective in future treatments. This underscores the importance of adhering to prescribed dosage regimens, completing the entire course of treatment, and only using antibiotics when truly necessary, as directed by a healthcare professional.

Furthermore, clarithromycin is not effective against all types of bacteria. Its spectrum of activity, while broad, doesn’t encompass all bacterial species. Therefore, appropriate testing to identify the infecting organism is essential to ensure the selected antibiotic is effective. Using clarithromycin against an inappropriate bacterial strain is not only ineffective but can also contribute to the development of resistance.

Finally, some patients may experience alterations in taste during treatment. This side effect, known as dysgeusia, can impact the enjoyment of food and beverages. While usually temporary, it can be bothersome for some individuals. This should be considered when weighing the risks and benefits of clarithromycin therapy, especially for patients who place high importance on taste and culinary experiences.

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