ALBUREX™ infusion solution 20% (100ml), vial 1pc

ALBUREX™ 20% Solution 100ml Buy Online

Alburex 20 Infusion Solution: A Comprehensive Overview

Maintaining adequate blood volume is critical in various medical situations. Alburex 20 Infusion Solution plays a vital role in restoring and maintaining this crucial volume, offering a valuable therapeutic option for healthcare professionals.

What is Alburex 20?

Alburex 20 is a sterile, clear to slightly viscous solution for intravenous infusion. It’s a human albumin solution containing 200 g/L of total protein, with at least 96% being human albumin. This high concentration makes it particularly effective in situations requiring rapid volume expansion.

The solution contains human albumin as its primary component, along with other excipients such as sodium N-acetyltryptophanate, sodium caprylate, and sodium chloride. It’s designed to be hyperoncotic to normal plasma, meaning it draws fluid from tissues into the bloodstream, increasing blood volume. The solution’s pH is typically between 6.7 and 7.3.

Alburex 20 is available in 50ml and 100ml vials, each containing a specific amount of human albumin.

Alburex 20 is primarily indicated for the restoration and maintenance of circulating blood volume. This is especially important in situations of hypovolemia, where blood volume is significantly reduced, often due to trauma, surgery, or severe burns. It can also be used in other conditions as determined by a physician.

Alburex 20 is administered intravenously as an infusion. The rate of infusion should be carefully controlled and monitored by a healthcare professional. Vital signs, including blood pressure and pulse rate, should be closely monitored throughout the infusion process to detect any adverse reactions or signs of fluid overload.

• Effective volume expander: Rapidly increases circulating blood volume.
• High albumin concentration: Provides a substantial amount of protein.
• Well-established safety profile: Extensive clinical use supports its safety.

• Potential for fluid overload: Careful monitoring is essential to prevent complications.
• Allergic reactions: Although rare, allergic reactions can occur.
• Sodium content: Considerable sodium content should be taken into account in patients with sodium restrictions.

Close monitoring of vital signs is crucial during and after administration. The infusion should be stopped immediately if signs of cardiovascular overload (headache, dyspnea, jugular vein congestion) or increased blood pressure occur. Patients with a history of allergic reactions to blood products should be closely observed. Alburex 20 should be used cautiously in patients with heart failure or other conditions where fluid overload could be detrimental.

Always consult a healthcare professional for proper use and dosage. This information is for general knowledge and does not substitute for professional medical advice. Specific instructions regarding administration and potential interactions should be obtained from a qualified healthcare provider.

What is Alburex 20?

Alburex 20 is a crucial human albumin solution designed for intravenous infusion. Its primary function is to effectively restore and maintain adequate circulating blood volume. This is achieved through its high concentration of albumin, a protein naturally found in human blood plasma, playing a vital role in maintaining blood’s osmotic pressure.

The solution’s 20% concentration (200 g/L of total protein, with at least 96% being human albumin) allows for rapid expansion of blood volume when needed. This is particularly beneficial in situations where significant blood loss or fluid depletion has occurred, such as after major surgery, trauma, or severe burns. The precise composition includes human albumin, along with carefully selected excipients like sodium N-acetyltryptophanate, sodium caprylate, sodium chloride, and water for injections; these components are included to ensure stability and compatibility with the body.

Alburex 20 is presented as a sterile, clear to slightly viscous liquid. Its appearance may vary slightly, ranging from almost colorless to shades of yellow, amber, or even green. This variation in color does not affect the efficacy or safety of the product and is a natural consequence of the manufacturing process and origin of the albumin from human plasma. The solution is packaged in single-use vials, typically available in 50ml and 100ml sizes.

Understanding the precise composition and properties of Alburex 20 is essential for healthcare professionals to effectively utilize its therapeutic benefits. This involves a careful consideration of both the high concentration of human albumin and the presence of excipients, ensuring the solution is administered safely and effectively to address the patient’s specific needs.

Composition and Properties

Alburex 20’s core component is human albumin, a crucial plasma protein responsible for maintaining the blood’s oncotic pressure. This 20% solution boasts a high concentration of 200 g/L of total protein, with at least 96% consisting of this vital albumin. This high concentration is key to its effectiveness as a rapid volume expander.

Beyond albumin, the formulation includes several essential excipients. These are carefully chosen to ensure stability, isotonicity, and compatibility with the human body. Specifically, sodium N-acetyltryptophanate and sodium caprylate contribute to the solution’s overall stability and prevent degradation. Sodium chloride adjusts the solution’s tonicity, ensuring it doesn’t cause adverse reactions upon administration. The inclusion of water for injections maintains sterility and facilitates smooth intravenous delivery.

The resulting solution is characterized by its hyperoncotic properties. This means it exerts a higher osmotic pressure than normal plasma, drawing fluid from the interstitial spaces (the spaces between cells) into the bloodstream. This mechanism is crucial for its ability to effectively increase circulating blood volume. The solution’s pH typically falls within the range of 6.7 to 7.3, ensuring compatibility and minimizing potential irritation to the vascular system.

The physical properties of Alburex 20 include its appearance as a clear to slightly viscous liquid. The color can vary, ranging from almost colorless to yellow, amber, or green hues. This natural variation is due to the source material (human plasma) and does not impact the product’s safety or efficacy. It’s supplied in sterile, single-use vials, typically available in 100ml and other volume sizes, each containing a precisely defined amount of albumin and excipients, ensuring consistent therapeutic delivery.

Therapeutic Indications

Alburex 20’s primary therapeutic indication centers on the critical need for volume expansion in various clinical scenarios. Its high concentration of human albumin makes it exceptionally effective in rapidly restoring and maintaining adequate circulating blood volume. This is particularly crucial in situations where significant blood loss or fluid depletion has occurred, compromising the body’s circulatory system and overall function.

Specific situations where Alburex 20 proves invaluable include cases of hypovolemic shock, a life-threatening condition characterized by severely reduced blood volume. This can arise from various causes, including major trauma, significant hemorrhage during surgery, or extensive burns. The rapid volume expansion provided by Alburex 20 helps stabilize the circulatory system, improving tissue perfusion and organ function, thus increasing the chances of patient survival.

Beyond acute hypovolemic situations, Alburex 20 also finds application in other contexts where maintaining adequate blood volume is essential. These situations might involve patients undergoing major surgical procedures where significant blood loss is anticipated, or those with conditions leading to chronic fluid loss or depletion. In such cases, Alburex 20’s ability to maintain oncotic pressure and support circulatory stability plays a significant role in patient recovery and well-being. Always consult relevant medical guidelines and professional medical advice before administering Alburex 20.

Furthermore, the use of Alburex 20 may be considered in situations where a colloid solution is deemed appropriate for volume expansion. The choice to utilize Alburex 20 should be based on a careful assessment of the patient’s condition, considering factors such as the severity of hypovolemia, the presence of co-morbidities, and the overall treatment plan. The decision to administer Alburex 20 should always be made by a qualified healthcare professional.

Administration and Monitoring

Alburex 20 is administered intravenously via infusion, a process requiring careful control and monitoring by a qualified healthcare professional. The rate of infusion must be adjusted according to the patient’s individual needs and response, ensuring safe and effective volume expansion without causing adverse effects. Pre-infusion assessment of the patient’s hemodynamic status is crucial, including vital signs such as blood pressure, heart rate, and respiratory rate.

Throughout the infusion, continuous monitoring of vital signs is essential. This allows for prompt detection of any potential complications, such as fluid overload, which can manifest as increased blood pressure, shortness of breath, or pulmonary edema. Careful observation for signs of allergic reactions, though rare, is also necessary. These reactions can range from mild skin rashes to more severe anaphylactic shock, requiring immediate intervention.

Post-infusion monitoring is equally important, focusing on continued assessment of the patient’s hemodynamic stability and overall response to the treatment. Regular monitoring of fluid balance, urine output, and electrolyte levels helps ensure that the therapy is effective and not causing any unintended consequences. Any signs of complications, such as fluid overload or allergic reactions, should be reported immediately to the healthcare provider for prompt management.

The specific rate of infusion and duration of therapy are determined by the treating physician, based on individual patient factors and clinical assessment. Factors such as the severity of hypovolemia, the patient’s overall health status, and the presence of any co-morbidities will influence the treatment plan. Close collaboration between the physician, nurse, and other healthcare professionals is paramount in ensuring safe and effective administration and monitoring of Alburex 20.

Pros

Alburex 20 offers several significant advantages in clinical settings where rapid volume expansion is critical. Its high concentration of human albumin (200g/L) allows for efficient and effective restoration of circulating blood volume, often proving crucial in life-threatening situations such as hypovolemic shock. This rapid action can be life-saving in emergency situations requiring immediate intervention.

The use of human albumin, a naturally occurring protein in the body, contributes to a generally well-tolerated profile. Unlike some synthetic volume expanders, Alburex 20 is less likely to trigger adverse reactions or cause significant electrolyte imbalances. This reduces the risk of complications associated with other volume expansion methods, contributing to a smoother and safer therapeutic experience for the patient.

Alburex 20 provides a substantial amount of protein, which is beneficial in situations where protein loss has occurred, such as in cases of severe burns or trauma. This protein replenishment supports the body’s healing processes and overall recovery. The product’s hyperoncotic properties efficiently draw fluid from the interstitial space into the vasculature, contributing to effective volume expansion.

Furthermore, Alburex 20’s established safety profile, supported by extensive clinical use, provides reassurance to healthcare professionals. Its predictable and reliable effects, combined with its ability to rapidly address hypovolemia, make it a valuable tool in the critical care setting. This reliability allows clinicians to confidently use Alburex 20 in a range of situations requiring volume expansion.

Cons

While Alburex 20 offers significant benefits, potential drawbacks warrant careful consideration. The most significant risk is fluid overload, a potentially serious complication arising from the rapid expansion of blood volume. This risk necessitates meticulous monitoring of vital signs and fluid balance throughout the infusion and post-infusion period. Early detection and management of fluid overload are crucial to prevent severe complications, such as pulmonary edema or heart failure.

Although rare, allergic reactions to human albumin are possible. These reactions can range from mild symptoms like skin rashes to severe anaphylactic shock, requiring immediate medical intervention. A thorough history of allergies, particularly to blood products, is essential before administering Alburex 20. Close observation of the patient for any signs of allergic reactions during and after infusion is crucial.

Alburex 20 contains a notable amount of sodium. This should be carefully considered when administering the solution to patients with conditions such as heart failure or hypertension, where sodium restriction is often advisable. Careful monitoring of electrolyte levels and fluid balance is essential to avoid exacerbating these conditions. The sodium content necessitates a cautious approach in vulnerable patient populations.

Finally, the cost of Alburex 20, relative to other volume expanders, may be a factor in some healthcare settings. While its effectiveness and safety profile justify its use in many situations, the cost-effectiveness compared to alternative therapies needs consideration within resource allocation decisions. Healthcare providers should carefully weigh the benefits against the cost when determining the appropriate course of treatment.

Additional Information

Precautions and Warnings

Prior to administering Alburex 20, a thorough assessment of the patient’s cardiovascular status is paramount. Patients with pre-existing heart conditions, such as congestive heart failure, should be carefully monitored for signs of fluid overload. The infusion rate should be adjusted accordingly, and close observation for any signs of worsening heart failure is crucial. Pre-existing hypertension also requires careful consideration and close monitoring during and after the infusion.

Patients with a history of allergic reactions to blood products or albumin should be approached with extreme caution. A detailed allergy history should be obtained, and appropriate pre-medications or monitoring strategies should be considered to minimize the risk of anaphylaxis. The availability of emergency resuscitation equipment and personnel should be ensured in case of severe allergic reactions. The infusion should be immediately discontinued at the first sign of an allergic reaction.

Close monitoring of vital signs, including blood pressure, pulse rate, and respiratory rate, is essential throughout the infusion process. Any significant changes in these parameters should prompt a reassessment of the infusion rate or even discontinuation if necessary. Regular monitoring of fluid balance, including urine output, helps assess the effectiveness of the therapy and detect potential fluid overload. This vigilant approach is crucial for patient safety.

Furthermore, the significant sodium content in Alburex 20 necessitates caution in patients with sodium-restricted diets or those with conditions such as renal impairment or liver disease. Careful monitoring of serum sodium levels and adjustment of the infusion rate might be necessary in such cases. Close collaboration among the healthcare team is essential to ensure patient safety and optimize treatment outcomes. The administration of Alburex 20 should always be guided by established clinical guidelines and professional medical judgment.